5.05758

Oxidized ATP (oATP)

• Sinónimos: Oxidized ATP (oATP), Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
• Fórmula empírica (notación de Hill): C₁₀H₁₄N₅O₁₃P₃
• Número de CAS: 71997-40-5
• Peso molecular: 505.17
• Número MDL: MFCD00056956
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥97% (HPLC)
• Nivel de calidad: 100
• Formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: water: 50 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: [Na].[P](=O)(O[P](=O)(OCC(OC([n]1c2ncnc(c2nc1)N)C=O)C=O)O)(O[P](=O)(O)O)O
• InChI: 1S/C10H14N5O13P3.Na/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);
• Clave InChI: KOCWSVPHHGJWHA-UHFFFAOYSA-N

Descripción

Descripción general

Oxidized ATP (oATP) is a Schiff-base-forming reagent is utilized as an antagonist at the P2X7 receptor for several years. It was initially identified as an affinity reagent for nucleotide-binding proteins. oATP reduces nuclear factor kappa B (NF-κB) activation and IL-8 release in cells lacking P2X7R, suggesting that some anti-inflammatory effects of oATP may not be solely attributed to the blockade of the P2X7R. This effect of oATP is reminiscent of the action of other natural or synthetic Schiff-base-forming reagents with immunomodulatory activity.[1]

Aplicación

Oxidized ATP (oATP) may be used to study its effects on the proinflammatory responses in human umbilical vein endothelial cells (HUVEC), HEK293 cells, and 1321N1 astrocytes that lack expression of P2X7R.[2]

Acciones bioquímicas o fisiológicas

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Vergani, A., et al. 2013. Diabetes62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946.

Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable