Our objective was to examine the pharmacokinetic/hemodynamic properties of inhaled isobutyl nitrite (ISBN) in rats. ISBN is one of the volatile organic nitrites that has been used primarily as a drug of abuse. Recent studies indicate, however, that these compounds
Review of the physiological effects of amyl, butyl, and isobutyl nitrites.
T J Haley
Clinical toxicology, 16(3), 317-329 (1980-05-01)
Inhaled isobutyl nitrite produced lung inflammation with increased macrophage TNF-alpha and nitric oxide production.
L S Soderberg et al.
Advances in experimental medicine and biology, 402, 187-189 (1996-01-01)
Epidemiological studies have identified abuse of nitrite inhalants as an independent co-factor in HIV infection and in Kaposi's sarcoma (KS) in AIDS patients. In the present study we investigated the ability of macrophages from mice exposed to isobutyl nitrite to
Isobutyl nitrite is representative of a group of inhalants abused primarily by male homosexuals; abuse of this drug may be a risk factor for AIDS or Kaposi's sarcoma. Using a 14-day exposure regimen, we previously reported that inhaled isobutyl nitrite
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