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Z2626

Sigma-Aldrich

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

Sinonimo/i:

L-694,599, Squalestatin

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About This Item

Formula empirica (notazione di Hill):
C35H43O14Na3
Numero CAS:
144541-82-2
Peso molecolare:
756.68
Numero MDL:
MFCD03788025
Codice UNSPSC:
12352106
NACRES:
NA.77

product name

Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial

Origine biologica

microbial

Livello qualitativo

200

Saggio

≥95% (HPLC)

Forma fisica

lyophilized powder

Solubilità

DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Applicazioni

Zaragozic acid A trisodium salt has been used as:
  • a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
  • a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
  • a cholesterol synthesis inhibitor in T cells

Azioni biochim/fisiol

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Note legali

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
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