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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Sinonimo/i:

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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5 MG
CHF 124.00
25 MG
CHF 500.00

CHF 124.00

Spedizione prevista il03 aprile 2025

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5 MG
CHF 124.00
25 MG
CHF 500.00

About This Item

Formula empirica (notazione di Hill):
C10H6N2O2
Numero CAS:
118409-57-7
Peso molecolare:
186.17
Numero MDL:
MFCD00133899
Codice UNSPSC:
12352200
ID PubChem:
24278041
NACRES:
NA.77

CHF 124.00

Spedizione prevista il03 aprile 2025

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Origine biologica

synthetic (organic)

Livello qualitativo

100

Saggio

≥98%

Stato

powder

Potenza

35 μM IC50

Solubilità

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
VTJXFTPMFYAJJU-UHFFFAOYSA-N

Informazioni sul gene

human ... CDK2(1017)

Applicazioni

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells[1]. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils[2].

Azioni biochim/fisiol

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[3],[4].

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCQ1112
MKCP4881
MKCF7678
MKCD6227
MKBW4965V

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Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
E Heim
Zeitschrift fur Psychosomatische Medizin und Psychoanalyse, 38(3), 207-226 (1992-01-01)
Stressors and health risks in medical professions are still largely ignored. A survey on different studies in nurses, students, doctors and dentists by this author is compared to results of other authors. Special attention is given to role-strain and health
Janusz Ligęza et al.
Acta biochimica Polonica, 58(3), 391-396 (2011-09-03)
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase
Sheung Kwan Lam et al.
The Plant journal : for cell and molecular biology, 60(5), 865-881 (2009-08-28)
Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
Nathalie Leborgne-Castel et al.
Plant physiology, 146(3), 1255-1266 (2008-01-11)
The plant defense elicitor cryptogein triggers well-known biochemical events of early signal transduction at the plasma membrane of tobacco (Nicotiana tabacum) cells, but microscopic observations of cell responses related to these early events were lacking. We determined that internalization of
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