T7665

Tyrphostin 51

≥98%

• Sinonimo/i: 2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene
• Formula empirica (notazione di Hill): C₁₃H₈N₄O₃
• Numero CAS: 126433-07-6
• Peso molecolare: 268.23
• NACRES: NA.77
• PubChem Substance ID: 24278756
• UNSPSC Code: 12352200
• MDL number: MFCD00133903
• Assay: ≥98%
• Form: powder

Proprietà

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98%
• form: powder
• potency: 0.8 μM IC₅₀
• solubility: DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
• storage temp.: 2-8°C
• SMILES string: NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N
• InChI: 1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
• InChI key: JKNOYWVMHPMBEL-UNXLUWIOSA-N
• Gene Information: human ... CDK2(1017), EGFR(1956)

Descrizione

Application

Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.

Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type N95 (US)