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B5936

Brefeldina A

Ready Made Solution, from Penicillium brefeldianum, 10 mg/mL in DMSO

Sinonimo/i:

γAcido ,4-diidrossi-2-(6-idrossi-1-eptenil)-4-ciclopentanecrotonico λ-lattone, Ascotossina, BFA, Cianeina, Decumbina

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Cambia visualizzazione
A voi/SKUDisponibilitàPrezzo
200 μL
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CHF 126.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C16H24O4
Numero CAS:
Peso molecolare:
280.36
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
25191

CHF 126.00


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biological source

Penicillium brefeldianum

Quality Segment

vapor pressure

0.56 hPa ( 20 °C)

form

ready-to-use solution

autoignition temp.

301 °C

concentration

10 mg/mL in DMSO

solubility

DMSO: 10 mg/mL

antibiotic activity spectrum

neoplastics

application(s)

advanced drug delivery

mode of action

cell membrane | interferes

shipped in

wet ice

storage temp.

2-8°C

SMILES string

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

InChI key

KQNZDYYTLMIZCT-KQPMLPITSA-N

Application

Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.

Biochem/physiol Actions

Altera la struttura e la funzione dell′apparato di Golgi; è un attivatore del ciclo della sfingomielina.
La brefeldina A (BFA) è un metabolita fungino che altera la struttura e la funzione dell′apparato di Golgi. La BFA è un attivatore del ciclo della sfingomielina. In cellule tumorali umane è stata osservata apoptosi mediata dalla brefeldina A.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.[1] BFA inhibits the transport of sphingomyelin to the surface of mammalian cells.[2] The ester derivatives of BFA exhibit anti-cancer properties.[3]

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Hygroscopic.Storage class (TRGS 510): Combustible liquids

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Questo articolo
B6542B7651M3536
Brefeldina A Ready Made Solution, from Penicillium brefeldianum, 10 mg/mL in DMSO

Sigma-Aldrich

B5936

Brefeldina A

Brefeldina A ≥99% (HPLC and TLC), BioXtra, Molecular Biology

Sigma-Aldrich

B6542

Brefeldina A

Brefeldina A from Penicillium brefeldianum, ≥99% (HPLC and TLC)

Sigma-Aldrich

B7651

Brefeldina A

description

Ready Made Solution, from Penicillium brefeldianum, 10 mg/mL in DMSO

description

≥99% (HPLC and TLC), BioXtra, Molecular Biology

description

from Penicillium brefeldianum, ≥99% (HPLC and TLC)

description

powder, BioReagent, suitable for cell culture

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

mode of action

cell membrane | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

enzyme | inhibits

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

300

form

ready-to-use solution

form

powder

form

powder

form

powder

application(s)

advanced drug delivery

application(s)

-

application(s)

-

application(s)

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C


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Classe di stoccaggio

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)



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Certificati d'analisi (COA)

Lot/Batch Number

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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How stable is the solution if kept at 4 ºC? thanks

    1 answer
    1. This product is a 10 mg/mL solution in DMSO. The recommended storage temperature is 2-8°C. Assuming proper handling and storage, the item will be stable until the recommended retest date reported on the lot specific Certificate of Analysis. The product is assigned a retest date of 2 years from the date of Quality Release.

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