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T5651

Sigma-Aldrich

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

Sinonimo/i:

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Formula empirica (notazione di Hill):
C11H17N3O8
Numero CAS:
4368-28-9
Peso molecolare:
319.27
Beilstein:
49176
Numero MDL:
MFCD00213719
Codice UNSPSC:
12352200
ID PubChem:
24900308

Forma fisica

powder

Disponibilità

not available in USA

pH

4.8

Solubilità

H2O: soluble (stable at pH 4-5 if stored frozen)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

Temperatura di conservazione

2-8°C

Stringa SMILE

OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
CFMYXEVWODSLAX-IXUBDLNJSA-N

Informazioni sul gene

rat ... Scnn1g(24768)

Applicazioni

Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.

Azioni biochim/fisiol

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Confezionamento

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Nota sulla preparazione

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300

Consigli di prudenza

P301 + P330 + P331 + P310

Classi di pericolo

Acute Tox. 1 Oral

Codice della classe di stoccaggio

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Thomas C Jaramillo et al.
Autism research : official journal of the International Society for Autism Research, 10(1), 42-65 (2016-08-06)
Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in
Miriam Michel et al.
Scientific reports, 9(1), 11888-11888 (2019-08-17)
Assessment of left ventricular mass (LVM) is important in the evaluation of patients with congenital heart disease (CHD) and cardiac magnetic resonance imaging (CMR) is the gold standard. Recent software allows LVM calculation by real-time 3-dimensional echocardiography (RT3DE). We investigated
Hao Yang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(8), 1467-1482 (2019-06-04)
Irreversible neuron loss following spinal cord injury (SCI) usually results in persistent neurological dysfunction. The generation of autologous neural stem cells (NSCs) holds great potential for neural replenishment therapies and drug screening in SCI. Our recent studies demonstrated that mature
Scott R Burks et al.
Theranostics, 9(19), 5517-5531 (2019-09-20)
Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channel
Jie Zhang et al.
Acta biochimica et biophysica Sinica, 51(6), 562-570 (2019-05-30)
The protein voltage-gated sodium channel Nav1.5 is highly upregulated in various types of cancer and, in general, promotes cancer cell invasiveness and metastatic progression. A previous study found that Nav1.5 was highly expressed in poorly differentiated oral squamous cell carcinoma
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