This product may be stored for several days at 4 °C. The product has not been evaluated for long term freezer storage. However, other sources note that stock solutions of kynurenic acid at 100 mM, initially prepared with 5 M NaOH and subsequently diluted with saline and the pH adjusted with 2 N HCl, may be stored at -20 °C. This information has not been validated. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/231/908/k3375pis.pdf
K3375
Kynurenic acid
Kynurenic acid
≥98% (HPLC), powder, NMDA receptor antagonist
Sinonimo/i:
4-Hydroxyquinoline-2-carboxylic acid
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250 MG
CHF 42.10
1 G
CHF 89.90
5 G
CHF 309.00
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Cambia visualizzazione
250 MG
CHF 42.10
1 G
CHF 89.90
5 G
CHF 309.00
About This Item
Formula empirica (notazione di Hill):
C10H7NO3
Numero CAS:
Peso molecolare:
189.17
Beilstein:
147451
Numero CE:
Numero MDL:
Codice UNSPSC:
12352106
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Kynurenic acid, ≥98%
Saggio
≥98%
Stato
powder
Punto di fusione
275 °C (dec.) (lit.)
Stringa SMILE
OC(=O)c1cc(O)c2ccccc2n1
InChI
1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
HCZHHEIFKROPDY-UHFFFAOYSA-N
Informazioni sul gene
human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901) , GUCA2A(2980) , GUCA2B(2981) , NGFR(4804) , SLC23A2(9962)
rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)
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Applicazioni
Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells[1] and human primary astrocytes.[2] It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K[3] and induced pluripotent stem cell (iPSC)-derived neurons cells.[4]
Azioni biochim/fisiol
Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA),[5] α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors.[6] It blocks kainic acid neurotoxicity.[7] Kynurenic acid also blocks nicotinic acetylcholine receptors.[8] It is a by-product of tryptophan catabolic pathway.[5] Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA).[9] KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases.[8][10] Normal levels of KynA in the brain is crucial for the cognitive function.[11]
Caratteristiche e vantaggi
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Articoli
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