Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

T1505

Sigma-Aldrich

Tetraisopropyl pyrophosphoramide

butyrylcholinesterase inhibitor

Sinonimo/i:

Tetra(monoisopropyl)pyrophosphortetramide, iso-OMPA

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C12H32N4O3P2
Numero CAS:
513-00-8
Peso molecolare:
342.36
Numero CE:
208-149-5
Numero MDL:
MFCD00048272
Codice UNSPSC:
12352202
ID PubChem:
24278724
NACRES:
NA.77

Origine biologica

synthetic

Punto di fusione

149-151 °C

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)
IOIMDJXKIMCMIG-UHFFFAOYSA-N

Informazioni sul gene

human ... ACHE(43) , BCHE(590)

Applicazioni

Tetraisopropyl pyrophosphoramide has been used:
  • as a butyrylcholinesterase inhibitor to determine the proportions of butyrylcholinesterase (BChE) in cat and tiger plasma[1]
  • to inhibit wild-type BChE in acetylcholinesterase assay[2]
  • to selectively block the enzymatic activity of AChE[3]

Azioni biochim/fisiol

Selective inhibitor of butyrylcholinesterase

Attenzione

WARNING: Extremely hazardous! Be aware of the risk and familiar with safety procedures before you use this product.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
BCCC2020
BCCB0397
BCBW4257
BCBQ3831V
BCBQ3831

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 8

1 of 8

Neostigmine bromide ≥98% (HPLC and titration), powder

Sigma-Aldrich

N2001

Neostigmine bromide

Acetylthiocholine iodide ≥99.0% (AT)

Sigma-Aldrich

01480

Acetylthiocholine iodide

Diisopropylfluorophosphate

Sigma-Aldrich

D0879

Diisopropylfluorophosphate

Paraoxon-ethyl ≥90%, oil

Sigma-Aldrich

D9286

Paraoxon-ethyl

Acetylcholine iodide ≥97%

Sigma-Aldrich

A7000

Acetylcholine iodide

Acetylcholinesterase Activity Assay Kit sufficient for 100 colorimetric tests

Sigma-Aldrich

MAK119

Acetylcholinesterase Activity Assay Kit

Spermidine trihydrochloride ≥98% (TLC)

Sigma-Aldrich

S2501

Spermidine trihydrochloride

Sodium fluoride ACS reagent, ≥99%

Sigma-Aldrich

201154

Sodium fluoride

Postnatal development of nitrergic and cholinergic structures in rat spinal cord
Bolekova A, et al.
Archives Italiennes de Biologie, 149(3), 293-302 (2011)
Liyi Geng et al.
PloS one, 8(6), e67446-e67446 (2013-07-11)
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.
Bartels CF, et al.
Biochemical Pharmacology, 60(4), 479-487 (2018)
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase
Wang YW, et al.
Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)
A A Kousba et al.
Toxicology, 188(2-3), 219-232 (2003-05-28)
The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects. These oxons also inhibit other cholinesterases (ChE) such
Visualizza tutti i documenti correlati

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.