T2877

3,3′,5-Triiodo-L-thyronine

synthetic (organic), ≥95% (HPLC), Thyroid hormone, powder

• Sinonimo/i: O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T₃
• Formula empirica (notazione di Hill): C₁₅H₁₂I₃NO₄
• Numero CAS: 6893-02-3
• Peso molecolare: 650.97
• NACRES: NA.32
• PubChem Substance ID: 24900088
• UNSPSC Code: 51111800
• EC Number: 229-999-3
• MDL number: MFCD00002593
• Beilstein/REAXYS Number: 2710227
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥95% (HPLC)

Proprietà

• Nome del prodotto: 3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder
• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
• technique(s): transfection: suitable
• mp: 234-238 °C (lit.)
• solubility: 4 M NH₄OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• InChI key: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• Gene Information: human ... THRA(7067), THRB(7068) ; rat ... Thra(81812), Thrb(24831)

Descrizione

Application

3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay.[1] The product can also be used for in vitro transfection of 293T cells.[2]

Biochem/physiol Actions

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function.[3] The product also positively regulates the hepatic FGF21 expression[2] and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.

Preparation Note

3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

Other Notes

This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877

Informazioni sulla sicurezza

• pictograms: GHS08
• signalword: Danger
• hcodes: H372
• pcodes: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• target_organs: Thyroid,Cardio-vascular system,Kidney
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves