Testosterone undecanoate is an orally available prodrug of testosterone that has a very long elimination half-life. It is an androgen and anabolic–androgenic steroid that acts as agonist of the androgen receptor (AR). Testosterone undecanoate is mainly used in the treatment of low testosterone levels in men. Also, it was approved for treatment of male hypogonadism.
orally available prodrug of testosterone that has a very long elimination half-life; androgen that acts as agonist of the androgen receptor (AR)
Male hypogonadism is often treated by testosterone (T) replacement therapy such as oral administration of the ester prodrug, testosterone undecanoate (TU). However, the systemic exposure to T following oral TU is very low due to esterase-mediated metabolism, particularly in the
Testosterone undecanoate and testosterone enanthate injections are both effective and safe in transmen over 5 years of administration
Clinical Endocrinology, 89(6), 878-886 (2018)
Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs
Journal of Pharmacology and Experimental Therapeutics, 306(3), 925-933 (2003)
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