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E8515

β-Estradiol 3-benzoate

≥97%

Sinonimo/i:

1,3,5(10)-Estratriene-3,17β-diol 3-benzoate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-benzoate, 3-Benzoyloxy-17β-estrol

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C25H28O3
Numero CAS:
Peso molecolare:
376.49
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-043-7
Beilstein/REAXYS Number:
3107526
MDL number:
Assay:
≥97%
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Quality Segment

assay

≥97%

mp

191-198 °C (lit.)

SMILES string

[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OC(=O)c5ccccc5)ccc24

InChI

1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1

InChI key

UYIFTLBWAOGQBI-BZDYCCQFSA-N

Application

β-Estradiol 3-benzoate has been used:to mimic estradiol in rat during the oestrous cycle in rats. It has also been used along with progesterone for the induction of sexual receptivity in female rat.
Used in a study of general steroid metabolism and clearing, as groundwork for anabolic steroid screening in athletes.

Biochem/physiol Actions

β-Estradiol 3-benzoate is a synthetic estrogen. It favors breast cancer progression. It is an endocrine disrupting chemicals. It interacts with endocrine system and cause harmful effect on reproduction in animals and humans. It binds to estrogen receptors and favors tumor metastatis in breast, prostate and bone cells.

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Questo articolo
E1600000BP3961251000
Estradiol benzoate European Pharmacopoeia (EP) Reference Standard

E1600000

Estradiol benzoate

Estradiol benzoate British Pharmacopoeia (BP) Reference Standard

BP396

Estradiol benzoate

Estradiol benzoate United States Pharmacopeia (USP) Reference Standard

USP

1251000

Estradiol benzoate

description

≥97%

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

assay

≥97%

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

mp

191-198 °C (lit.)

mp

191-198 °C (lit.)

mp

191-198 °C (lit.)

mp

191-198 °C (lit.)


Pittogrammi

Health hazard

Parola di avvertenza

Danger

Codici di pericolo

Hazard Classifications

Carc. 2 - Repr. 1B

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Che succede?

WGK 3

DPI (dispositivi di protezione individuale)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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Questions

1–2 of 2 Questions  
  1. If dissolved in corn oil, how is the stability? What is the recommended storage temperature and duration?

    1 answer
    1. The stability of this product in corn oil has not been investigated. However, various external sources indicate that Estradiol benzoate may be stored in aliquots at -80°C for 2 years and -20°C for 1 year when prepared at 2.5 mg/mL or greater in a mixture of 1 part DMSO and 9 parts corn oil.

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  2. How should stock solutions for the product β-Estradiol 3-benzoate (E8515) be stored?

    1 answer
    1. Once the solution is prepared, it should be stored in separate packages to prevent product failure due to repeated freezing and thawing. The recommended storage period for the stock solution is as follows: when stored at -80°C, it should be used within 6 months; when stored at -20°C, it should be used within 1 month. To enhance solubility, the tube can be heated to 37°C and then agitated in an ultrasonic bath for a period of time.

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