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Merck
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SML1924

Sigma-Aldrich

T1AM

≥98% (HPLC)

Sinonimo/i:

3-Iodothyronamine hydrochloride, 4-[4-(2-Aminoethyl)-2-?iodophenoxy]phenol hydrochloride (1:1)

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About This Item

Formula empirica (notazione di Hill):
C14H14INO2 · HCl
Numero CAS:
788824-64-6
Peso molecolare:
391.63
Numero MDL:
MFCD11973725
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

H2O: 10 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1.[H]Cl

InChI

1S/C14H14INO2.ClH/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12;/h1-6,9,17H,7-8,16H2;1H
RVKVVMXTPQCCIX-UHFFFAOYSA-N

Azioni biochim/fisiol

3-iodothyronamine (T1AM) is present in vertebrate tissues and the circulatory system. Its physiological effects are the opposite of the thyroid hormone. T1AM acts as a neuromodulator as well as a hormone-like molecule.
T1AM (3-Iodothyronamine) is an endogenous biogenic amine derived from thyroid hormone. T1AM is a potent agonist of trace amine-associated receptor TAAR1 (TAR1, TA1), a GPCR primarily found in the brain.

Pittogrammi

Exclamation markEnvironment
GHS07,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Carolin Stephanie Hoefig et al.
Thyroid : official journal of the American Thyroid Association, 26(12), 1656-1673 (2016-09-22)
Thyronamines (3-T
Alexandra G Ianculescu et al.
Molecular bioSystems, 6(8), 1338-1344 (2010-07-14)
3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T(1)AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism. The structural
Annunziatina Laurino et al.
European journal of pharmacology, 793, 35-42 (2016-11-07)
3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a modulatory role on the monoaminergic
Muhammad Zahid Khan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 439-449 (2016-10-25)
Human trace amines (TAs) are endogenous compounds, previously almost ignored in human pathology for many reasons (difficulty of their measurement in biological fluids, unknown receptors for elusive amines), are now considered to play a significant role in synaptic transmission within

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