SML1845

Thapsigargin

From (Thapsia garganica L seeds), ≥98% (HPLC), calcium ion pumps inhibitor, DMSO solution

• Sinonimo/i: CHEBI:9516, CHEMBL96926, MFCD00083511, UNII-Z96BQ26RZD, Z96BQ26RZD, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
• Formula empirica (notazione di Hill): C₃₄H₅₀O₁₂
• Numero CAS: 67526-95-8
• Peso molecolare: 650.75
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: DMSO solution

Proprietà

• Nome del prodotto: Thapsigargin Ready Made Solution, ≥98% (HPLC), 10 mM in DMSO
• biological source: (Thapsia garganica L seeds)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: DMSO solution
• concentration: 10 mM in DMSO
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O1[C@@H]2[C@]([C@H](C[C@@]([C@H]3[C@@H]([C@H](C(=C32)C)OC(=O)\C(=C/C)\C)OC(=O)CCCCCCC)(OC(=O)C)C)OC(=O)CCC)([C@@](C1=O)(O)C)O
• InChI: 1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
• InChI key: IXFPJGBNCFXKPI-FSIHEZPISA-N

Descrizione

Application

Thapsigargin Ready Made Solution has been used as a negative control in in vivo growth and in vitro translation measurements.

Biochem/physiol Actions

Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues.

Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues. The inhibition of calcium ion pumps causes intracellular increase of calcium ion levels. It was found that thapsigargin at 100 nM concentration effectively inhibited the SR Ca²⁺- adenosine triphosphatase (ATPase) in cardiac and skeletal muscles. Thapsigargin was also reported to be effective in blocking autophagy by interfering with the autophagosome-lysosome fusion.

Other Notes

Thapsigargin Ready Made Solution is provided at 10 mM concentration in DMSO. The solution can be further diluted with DMSO to a concentration of 2 mM. It is recommended to store Thapsigargin Ready Made Solution in small aliquots at -20 °C.

Informazioni sulla sicurezza

• Classe di stoccaggio: 10 - Combustible liquids
• Che succede?: WGK 2
• Punto di infiammabilità (°F): 188.6 °F - closed cup
• Punto di infiammabilità (°C): 87 °C - closed cup