SML0315
CORM-A1
≥95% (NMR)
Sinonimo/i:
Sodium boranocarbonate
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10 MG
CHF 114.00
50 MG
CHF 454.00
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Cambia visualizzazione
10 MG
CHF 114.00
50 MG
CHF 454.00
About This Item
Formula empirica (notazione di Hill):
CH3BNa2O2
Numero CAS:
Peso molecolare:
103.82
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥95% (NMR)
Stato
powder
Condizioni di stoccaggio
desiccated
Colore
white to beige
Solubilità
H2O: >15 mg/mL
Temperatura di conservazione
room temp
Stringa SMILE
[Na+].[Na+].[BH3-]C([O-])=O
InChI
1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1
SOFPSQNQOQPAAJ-UHFFFAOYSA-M
Applicazioni
CORM-A1 has been used:
- to deliver carbon monoxide (CO) and to test its cytoprotection in yeast and primary astrocytes culture during oxidative stress[1]
- as CO donor in murine macrophages J774A.1 cells to test its effect on cellular β-endorphins elevation[2]
- to test its effect on mitophagy activation in retinal ganglion cells[3]
Azioni biochim/fisiol
CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase is an important gaseous signaling mediator in mammalian cells CORM-A1 has anti-oxidant and anti-inflammatory activity.
CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Helena Parfenova et al.
American journal of physiology. Heart and circulatory physiology, 315(4), H978-H988 (2018-07-22)
Neonatal asphyxia leads to cerebrovascular disease and neurological complications via a mechanism that may involve oxidative stress. Carbon monoxide (CO) is an antioxidant messenger produced via a heme oxygenase (HO)-catalyzed reaction. Cortical astrocytes are the major cells in the brain
Sara R Oliveira et al.
The European journal of neuroscience, 52(1), 2771-2780 (2020-03-14)
Previous studies about the modulation of the vasculature by CO were performed exclusively in male or sexually immature animals. Understanding the sex differences regarding systemic drug processing and pharmacodynamics is an important feature for safety assessment of drug dosing and
Kapil K Upadhyay et al.
Redox biology, 28, 101314-101314 (2019-09-13)
Nuclear factor-erythroid 2 related factor 2 (Nrf2)-mediated signaling plays a central role in maintaining cellular redox homeostasis of hepatic cells. Carbon monoxide releasing molecule-A1 (CORM-A1) has been reported to stimulate up-regulation and nuclear translocation of Nrf2 in hepatocytes. However, the
Cláudia Figueiredo-Pereira et al.
FEMS yeast research, 19(5) (2019-07-26)
Autophagy is an autodigestive process, promoting cytoprotection by the elimination of dysfunctional organelles, misfolded proteins and toxic aggregates. Carbon monoxide (CO) is an endogenous gasotransmitter that under low concentrations prevents cell death and inflammation. For the first time, the role
Cláudia Figueiredo-Pereira et al.
Redox biology, 32, 101470-101470 (2020-03-03)
Carbon monoxide (CO) is a gasotransmitter endogenously produced by the activity of heme oxygenase, which is a stress-response enzyme. Endogenous CO or low concentrations of exogenous CO have been described to present several cytoprotective functions: anti-apoptosis, anti-inflammatory, vasomodulation, maintenance of
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