SAB4200795

Anti-Exendin-4 antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Anti-Exenatide
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 200
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• Concentrazione: ~1 mg/mL
• tecniche: indirect ELISA: 0.125-0.25 μg/mL using 1 μg/mL Exendin-4 protein for coating
• N° accesso UniProt: P26349
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified

Descrizione

Descrizione generale

Exendin-4 is an incretin mimetic 39-amino-acid peptide found in venom from the Gila monster (Helicoderma suspectum). Exendin-4 belongs to the glucagon-secretin family of peptide hormones and neuropeptides. It acts as a potent agonist of the GLP-1 receptor and is an insulinotropic agent (promotes insulin secretion) with a long half-life.

Exendin-4 mimics the activity of mammalian incretin hormone glucagon-like peptide 1 (GLP-1) and thus play a role in the control of glucose. This includes the secretion of insulin in a glucose-dependent manner, negative regulation of high glucagon secretion, and increased duration of stomach emptying. In type 2 diabetes patients, this peptide can be administered subcutaneously for glycemic control, when metformin is unable to produce adequate results. Exendin-4 promotes the neogeneration and proliferation of β-cells, and thus aids in the regeneration of pancreas. It acts as a ligand to exendin receptor and leads to an elevation of acinar cell cAMP levels.

Anti-Exendin-4 antibody specifically recognizes synthetic Exendin-4 and does not cross react with GLP-1.

Immunogeno

synthetic peptide corresponding to the C-terminal sequence of Heloderma suspectum (Gila monster) Exendin-4 , conjugated to KLH

Applicazioni

The antibody may be used in various immunochemical techniques including ELISA

Stato fisico

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Altre note

This product is for R&D use only, not for drug, household, or other uses.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable