E7269

Exendin Fragment 9-39

≥95% (HPLC)

• Formula empirica (notazione di Hill): C₁₄₉H₂₃₄N₄₀O₄₇S
• Numero CAS: 133514-43-9
• Peso molecolare: 3369.76
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD00283195

Proprietà

• Quality Level: 200
• assay: ≥95% (HPLC)
• form: powder
• mol wt: 3369.76 g/mol
• storage condition: (Keep container tightly closed in a dry and well-ventilated place)
• technique(s): protein expression: suitable
• solubility: water: 1.00-1.04 mg/mL, clear, colorless
• UniProt accession no.: P01275, P43220
• storage temp.: −20°C
• SMILES string: S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CC(C)C)CO)CCCCN)CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C

Descrizione

Application

Exendin Fragment 9-39 has been used to study its effect on basal microvascular permeability.[1]It has also been used as a glucagon-like peptide-1 receptor (GLP-1R) antagonist:

• to study to determine whether Ex-4 a GLP-1R agonist acts through GLP-1R, in mouse skeletal muscle cell line[2]
• to study its effects on the adaptation of islets in glucose-dependent insulinotropic polypeptide knockout mice[3]
• to study its in vivo effects on GLP-1 signaling on insulin response in mice[4]

Biochem/physiol Actions

Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of the glucose-dependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP.[5]GLP-1, along with GIP, acts as a physiological incretin.[6]

Other Notes

Lyophilized from 0.1% TFA in H2O

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)