S4264
Spermine
suitable for cell culture, BioReagent
Sinonimo/i:
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
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1 G
CHF 90.30
5 G
CHF 290.00
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Cambia visualizzazione
1 G
CHF 90.30
5 G
CHF 290.00
About This Item
Formula condensata:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Numero CAS:
Peso molecolare:
202.34
Beilstein:
1750791
Numero CE:
Numero MDL:
Codice UNSPSC:
12352204
ID PubChem:
NACRES:
NA.75
Prodotti consigliati
Origine biologica
microbial
synthetic
Livello qualitativo
Nome Commerciale
BioReagent
Saggio
≥96%
Stato
solid
tecniche
cell culture | mammalian: suitable
P. ebollizione
150 °C/5 mmHg (lit.)
Punto di fusione
28-30 (lit.)
Solubilità
H2O: 50 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
PFNFFQXMRSDOHW-UHFFFAOYSA-N
Informazioni sul gene
human ... GRIN2B(2904)
rat ... Grin2a(24409)
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Applicazioni
Spermine has been used:
- in the buffer, to swap the divalent cations in the MgSO4 protocol to stabilize the integrity of the chromosomes[1]
- in the preparation of modified mica surfaces from freshly cleaved mica surfaces[2]
- to study its effects on survival in mice with sepsis and to estimate the role of spermine in lethal systemic inflammatory diseases[3]
Azioni biochim/fisiol
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Avvertenze
Danger
Indicazioni di pericolo
Classi di pericolo
Eye Dam. 1 - Skin Corr. 1B
Codice della classe di stoccaggio
8A - Combustible corrosive hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Dextran-spermine cationic polysaccharide was prepared by means of reductive amination between oxidized dextran and the natural oligoamine spermine. The formed Schiff-base imine-based conjugate was reduced with borohydride to obtain the stable amine-based conjugate. The transfection efficiency of the synthetic dextran-spermine
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