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Documenti fondamentali

N193

Sigma-Aldrich

1-Naphthylacetyl spermine trihydrochloride

Sinonimo/i:

NASPM trihydrochloride

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5 MG
CHF 186.00
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CHF 633.00

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5 MG
CHF 186.00
25 MG
CHF 633.00

About This Item

Formula empirica (notazione di Hill):
C22H34N4O · 3HCl
Numero CAS:
Peso molecolare:
479.91
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77

CHF 186.00


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Saggio

≥95% (HPLC)

Livello qualitativo

Stato

powder

Condizioni di stoccaggio

desiccated
protect from light

Colore

white

Solubilità

H2O: ≥20 mg/mL

Stringa SMILE

Cl.Cl.Cl.NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12

InChI

1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
JNEOJAUJWOPWJS-UHFFFAOYSA-N

Applicazioni

1-Naphthylacetyl spermine trihydrochloride has been used for the inhibition of calcium-permeable AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor).[1] It has also been used to study the involvement of AMPAR in biphasic activation of stress-activated protein kinase/extracellular signal-regulated kinase-1.[2]

Azioni biochim/fisiol

Blocks Ca2+ permeable AMPA receptor channels.

Altre note

Synthetic analog of Joro spider toxin.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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K Oguro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9218-9227 (1999-10-26)
Considerable evidence suggests that Ca(2+)-permeable AMPA receptors are critical mediators of the delayed, selective neuronal death associated with transient global ischemia and sustained seizures. Global ischemia suppresses mRNA and protein expression of the glutamate receptor subunit GluR2 and increases AMPA
Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction.
Fernandes, et al.
Nature Communications, 14, 3352-3352 (2023)
Cornelia Strobel et al.
The Journal of physiology, 595(16), 5653-5669 (2017-06-09)
Dendritic and spine calcium imaging in combination with electrophysiology in acute slices revealed that in medial intercalated cells of the amygdala: Action potentials back-propagate into the dendritic tree, but due to the presence of voltage-dependent potassium channels, probably Kv4.2 channels
Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus
Zhang Q, et al
Neuroscience Letters, 337(1), 51-55 (2003)
A Takazawa et al.
Brain research, 706(1), 173-176 (1996-01-08)
The anticonvulsant effect of 1-naphthylacetyl spermine (1-NA-Spm), an analogue of Joro spider toxin, against amygdaloid kindled seizures was studied in rats. 1-NA-Spm (10, 20 and 40 micrograms/rat) dose-dependently improved kindled seizures and shortened the afterdischarge duration 30 min after the

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