P9255

Pyridoxal 5′-phosphate hydrate

≥98%

• Sinonimo/i: Pyridoxal phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate
• Formula empirica (notazione di Hill): C₈H₁₀NO₆P · xH₂O
• Numero CAS: 853645-22-4
• Peso molecolare: 247.14 (anhydrous basis)
• Beilstein: 234749
• Numero CE: 200-208-3
• Numero MDL: MFCD00006333
• Codice UNSPSC: 12352205
• ID PubChem: 24899020
• NACRES: NA.79

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98%
• Stato: powder
• tecniche: HPLC: suitable
• Colore: beige; off-white to yellow
• Punto di fusione: 140-143 °C
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
• InChI: 1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14); NGVDGCNFYWLIFO-UHFFFAOYSA-N

Descrizione

Descrizione generale

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway.[1] It is the active form of pyridoxine.[2]

Applicazioni

Pyridoxal 5′-phosphate hydrate has also been used:

• as a reference standard to quantify vitamin B₆ in feed and digesta samples using high performance liquid chromatography (HPLC)[3]
• in D-amino acid transaminase reaction(10)
• as a cofactor for L-glutamic acid decarboxylase[4]

Azioni biochim/fisiol

Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis.[2] PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS)[5] cysteine desulfurase,[6] cystathionine γ-synthase (CGS),[7] ornithine 4,5-aminomutase (OAM),[8] and D-serine dehydratase.[9]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)