P8761

Probenecid

≥98% (NaOH, titration), powder, uricosuric agent

• Sinonimo/i: Acido p-(dipropilsulfamoil)benzoico
• Formula empirica (notazione di Hill): C₁₃H₁₉NO₄S
• Numero CAS: 57-66-9
• Peso molecolare: 285.36
• Numero CE: 200-344-3
• Numero MDL: MFCD00038402
• Codice UNSPSC: 12161501
• ID PubChem: 24898976
• NACRES: NA.77

Proprietà

• product name: Probenecid,
• Saggio: ≥98% (NaOH, titration)
• Ideatore: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Stringa SMILE: CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
• InChI: 1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16); DBABZHXKTCFAPX-UHFFFAOYSA-N
• Informazioni sul gene: human ... SLC22A11(55867) , SLC22A6(9356) , SLC22A8(9376)

Descrizione

Applicazioni

Probenecid has been used:

• as a component of phenol red free Hank′s buffer for Intracellular Ca²⁺-mobilization assay
• as a component of calcium sensitive dye for calcium mobilization Studies
• as a supplement in Hank′s balanced salt solution (HBSS) assay buffer

Useful as an inhibitor of the organic anion transporter, MRP.

Azioni biochim/fisiol

Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P301 + P312 + P330
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves