E1127

β-Estradiol 17-(β-D-glucuronide) sodium salt

• Sinonimo/i: 1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide
• Formula condensata: C₂₄H₃₁O₈Na
• Numero CAS: 15087-02-2
• Peso molecolare: 470.49
• Numero MDL: MFCD00056557
• Codice UNSPSC: 51111800
• ID PubChem: 24894388
• NACRES: NA.77

Proprietà

• Sterilità: non-sterile
• Saggio: ≥98% (HPLC)
• Stato: powder
• Solubilità: 0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
• InChI: 1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;; GPLPNZUTAJWRLU-UHFFFAOYSA-N

Descrizione

Applicazioni

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay.[1] It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).[2][3]

Azioni biochim/fisiol

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.[4]

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332,H351
• Consigli di prudenza: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges