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P2076

Sigma-Aldrich

Polymyxin B nonapeptide hydrochloride

lyopholized powder

Sinonimo/i:

PMBN

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5 MG
CHF 212.00

CHF 212.00

Spedizione prevista il29 maggio 2025

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5 MG
CHF 212.00

About This Item

Formula empirica (notazione di Hill):
C43H74N14O11 · xHCl
Peso molecolare:
963.13 (free base basis)
Numero MDL:
MFCD00214217
Codice UNSPSC:
12352209
ID PubChem:
24898270
NACRES:
NA.26

CHF 212.00

Spedizione prevista il29 maggio 2025

Richiedi un ordine bulk

Nome del prodotto

Polymyxin B nonapeptide hydrochloride, cationic cyclic peptide

Livello qualitativo

200

Stato

lyophilized powder

Colore

white to light yellow

applicazioni

cell analysis

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC(=O)C(CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC1=O)C(C)O)NC(=O)C(CCN)NC(=O)C(N)C(C)O

InChI

1S/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64)
PYHYGIPVYYRJHU-UHFFFAOYSA-N

Applicazioni

Polymyxin B nonapeptide hydrochloride has been used as an outer membrane permeabilizer, to characterize PAßN activity on membrane.[1] It has been used as a control in antibacterial assays.[2]

Azioni biochim/fisiol

PMBN has endotoxin-neutralizing activity and thus can be utilized in adjunctive therapy against Gram-negative sepsis. It has been found that PMBN is less toxic than polymyxin B. Unlike polymyxin B, PMBN does not exhibit neurotoxicity and nephrotoxicity. While it retains the anti endotoxin property of the parent compound, it is much less potent.[3]
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.[4][5][6] PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.[7]
Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000378623
0000362520
0000362520
0000378623
0000298783

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Colistina ≥19,000 IU/mg

Sigma-Aldrich

C4461

Colistina

vibrant-m

P2400000

Polymyxin B sulfate

vibrant-m

Y0000355

Polymyxin B sulfate for microbiological assay

Tunicamicina

Sigma-Aldrich

T7765

Tunicamicina

Vancomicina ≥900 μg per mg (as vancomycin base)

Sigma-Aldrich

V2002

Vancomicina

Mariana Castanheira et al.
International journal of antimicrobial agents, 56(1), 106011-106011 (2020-05-18)
This study examined ceftazidime-avibactam activity against carbapenem-resistant Enterobacterales (CRE) clinical isolates and resistance mechanisms among non-metallo β-lactamase (MBL) producers displaying ceftazidime-avibactam MIC values at 4 mg/L. CRE isolates (286 of 8161 Enterobacterales) collected in Asia-Pacific, Europe and Latin America during
Haim Tsubery et al.
Molecular pharmacology, 62(5), 1036-1042 (2002-10-23)
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, is capable of specifically increasing the permeability of the outer membrane (OM) of Gram-negative bacteria toward hydrophobic antibiotics. In this study, we evaluated the contribution
Hua-Ju Liang et al.
Archiv der Pharmazie, 353(3), e1900294-e1900294 (2020-01-03)
A series of (3-benzyl-5-hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug-resistant Gram-positive bacteria. The compounds are ineffective against all tested Gram-negative bacteria. The structure of the ester group exerted a profound
M Vaara
Microbiological reviews, 56(3), 395-411 (1992-09-01)
The outer membrane of gram-negative bacteria provides the cell with an effective permeability barrier against external noxious agents, including antibiotics, but is itself a target for antibacterial agents such as polycations and chelators. Both groups of agents weaken the molecular
Hongfei Pi et al.
Frontiers in microbiology, 11, 1556-1556 (2020-08-28)
Multidrug-resistant (MDR) pathogens, particularly the ESKAPE group (Enterococcus faecalis/faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter spp.), have become a public health threat worldwide. Development of new antimicrobial classes and the use of drugs in
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