11702

Bacitracin

from Bacillus licheniformis, ≥65 IU/mg

• Sinonimo/i: Altracin, Bacitracin A
• Formula empirica (notazione di Hill): C₆₆H₁₀₃N₁₇O₁₆S
• Numero CAS: 1405-87-4
• Peso molecolare: 1422.69
• Numero CE: 215-786-2
• Numero MDL: MFCD00062640
• Codice UNSPSC: 51282002
• ID PubChem: 57646949
• NACRES: NA.85

Proprietà

• Origine biologica: Bacillus licheniformis
• Livello qualitativo: 200
• Stato: powder
• Attività specifica: ≥65 IU/mg
• Colore: white to pale buff
• Spettro attività antibiotica: Gram-positive bacteria
• Modalità d’azione: cell wall synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [H]N1[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(N)C(C)CC)[C@@H](C)CC)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](Cc4ccccc4)C1=O
• InChI: 1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1; CLKOFPXJLQSYAH-RNHDWVCBSA-N

Descrizione

Descrizione generale

Chemical structure: peptide

Applicazioni

Bacitracin is used to study disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is also used to study the biosynthesis of sterols and squalene.
Bacitracin has been used:

• as a protease inhibitor[1]
• as a control antibiotic[2]
• for the calibration in size exclusion chromatography[3]

Azioni biochim/fisiol

Bacitracin has been shown to decrease vancomycin-resistant Enterococcus faecium population in intestine.[4]

Bacitracin is a peptide antibiotic.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

Confezionamento

5G, 25 G

Altre note

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)