Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

P0113

Sigma-Aldrich

PQ401

≥98% (HPLC), powder

Sinonimo/i:

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali

Scegli un formato

10 MG
CHF 193.00

CHF 193.00

Check Cart for Availability
Richiedi un ordine bulk
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
10 MG
CHF 193.00

About This Item

Formula empirica (notazione di Hill):
C18H16ClN3O2
Numero CAS:
196868-63-0
Peso molecolare:
341.79
Numero MDL:
MFCD00160558
Codice UNSPSC:
12352200
ID PubChem:
24724567
NACRES:
NA.77

CHF 193.00

Check Cart for Availability
Richiedi un ordine bulk

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

white

Solubilità

DMSO: >10 mg/mL
H2O: <2 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23

InChI

1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
YBLWOZUPHDKFOT-UHFFFAOYSA-N

Applicazioni

PQ401 has been used as:
  • an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression[1]
  • a reference inhibitor in dose-response measurements studies[2]
  • an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition[3]

Azioni biochim/fisiol

PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
PQ401, a diaryl urea compound that serves as an anti-glioma agent.[4]

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
023M4602V
027K46103
027K46102
027K46101
027K4610

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Monica Brenca et al.
The Journal of pathology, 238(4), 543-549 (2015-11-27)
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. The vast majority of GISTs are driven by oncogenic activation of KIT, PDGFRA or, less commonly, BRAF. Loss of succinate dehydrogenase complex activity has been identified
Gang Xi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)
Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts
Jung-Min Choi et al.
Lung cancer (Amsterdam, Netherlands), 90(2), 175-181 (2015-09-08)
Lung cancer is the commonly diagnosed cancer and is the leading cause of cancer-related mortality worldwide. The most prevalent form of lung cancer is NSCLC, comprising 80% of all lung cancer cases, and epidermal growth factor receptor (EGFR) is frequently
Maria Giovanna Scioli et al.
Journal of tissue engineering and regenerative medicine, 11(8), 2398-2410 (2016-04-15)
Osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis and progressive joint destruction. Bioengineered scaffolds are widely studied for regenerative surgery strategies in osteochondral defect management, also combining the use of stem cells, growth
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing
Visualizza tutti i documenti correlati

Articoli

InsR

We offers many products related to InsR for your research needs.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.