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M9020

Sigma-Aldrich

Mecamylamine hydrochloride

≥98% (TLC), powder, nAChR antagonist

Sinonimo/i:

2-(Methylamino)isocamphane hydrochloride, Inversine, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

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5 MG
CHF 65.40
25 MG
CHF 244.00
100 MG
CHF 730.00

CHF 65.40

Spedizione prevista il30 marzo 2025

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Cambia visualizzazione
5 MG
CHF 65.40
25 MG
CHF 244.00
100 MG
CHF 730.00

About This Item

Formula empirica (notazione di Hill):
C11H21N · HCl
Numero CAS:
826-39-1
Peso molecolare:
203.75
Numero CE:
212-555-8
Numero MDL:
MFCD00151462
Codice UNSPSC:
12352116
ID PubChem:
24277851
NACRES:
NA.77

CHF 65.40

Spedizione prevista il30 marzo 2025

Richiedi un ordine bulk

Nome del prodotto

Mecamylamine hydrochloride,

Stato

powder

Livello qualitativo

200

Solubilità

ethanol: 122 mg/mL
H2O: 47 mg/mL
isopropanol: 476 mg/mL
glycerol: 95 mg/mL

Ideatore

AstraZeneca

Stringa SMILE

Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C

InChI

1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
PKVZBNCYEICAQP-CIISUUNXSA-N

Informazioni sul gene

human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

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Applicazioni

Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input.[1][2] It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons[3] and in MLO-Y4 cells.[4]

Azioni biochim/fisiol

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Avvertenza

Solutions are stable to autoclaving.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000130932
0000202385
0000365352
0000365353
0000365354

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Acetylcholine affects osteocytic MLO-Y4 cells via acetylcholine receptors
Ma Y, et al.
Molecular and cellular endocrinology, 384(1-2), 155-164 (2014)
M I Damaj et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1284-1291 (1999-11-24)
Pharmacological mechanisms involved in nicotine-induced seizures were investigated in mice by testing the ability of several nicotinic agonists in producing seizures after peripheral administration. In addition, nicotinic antagonists such as hexamethonium, mecamylamine, dihydro-beta-erythroidine, and methyllycaconitine citrate (MLA) were used in
G Panagis et al.
Synapse (New York, N.Y.), 35(1), 15-25 (1999-12-01)
In the present study the neuronal expression of Fos, the protein product of c-fos, was used to study changes in neuronal activity in nerve terminal regions of the ascending dopaminergic system during nicotine withdrawal. Rats were infused for 14 days
Potential roles of ATP and local neurons in the monitoring of blood O2 content by rat aortic bodies
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Experimental Physiology, 99(1), 248-261 (2014)
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The Q-system is a binary expression system that works well across species. Here, we report the development and demonstrate the applications of a split-QF system that drives strong expression in Drosophila, is repressible by QS, and is inducible by a
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