The recommended storage temperature for this product is for –20°C. The stability of this product at –80°C has not been evaluated. This compound is not directly soluble in water. However, product R9532, Pyocyanin, Ready Made Solution, is a 5 mg/mL solution in DMSO. This item has a general shelf live of 2 years at –20°C. The prepared solution is not stable when stored at refrigerated temperatures. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/429/027/p0046dat.pdf
P0046
Pyocyanin
from Pseudomonas aeruginosa, ≥98% (HPLC), solid, redox-active phenazine
Sinonimo/i:
5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin
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5 MG
CHF 171.00
25 MG
CHF 581.00
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5 MG
CHF 171.00
25 MG
CHF 581.00
About This Item
Formula empirica (notazione di Hill):
C13H10N2O
Numero CAS:
Peso molecolare:
210.23
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Pyocyanin, from Pseudomonas aeruginosa, ≥98% (HPLC)
Origine biologica
Pseudomonas aeruginosa
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Solubilità
DMSO: soluble
acetone: soluble
chloroform: soluble
ethanol: soluble
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Stringa SMILE
CN1c2ccccc2N=C3C(=O)C=CC=C13
InChI
1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3
YNCMLFHHXWETLD-UHFFFAOYSA-N
Azioni biochim/fisiol
Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.
Nota sulla preparazione
For the preparation of an aqueous solution, dissolve pyocyanin in ethanol using 10% of the final required volume and then add distilled water to complete the volume.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Eye Irrit. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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