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M1434

Sigma-Aldrich

2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate

solid, ≥98% (HPLC)

Sinonimo/i:

2-MeSAMP, 2-Methylthio-AMP triethylammonium salt hydrate

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About This Item

Formula empirica (notazione di Hill):
C11H16N5O7PS · xC6H15N × yH2O
Numero CAS:
22140-20-1
Peso molecolare:
393.31 (anhydrous free acid basis)
Codice UNSPSC:
41106305
eCl@ss:
32160414
ID PubChem:
24896647
NACRES:
NA.51

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

H2O: 20 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

O.CCN(CC)CC.CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1

InChI

1S/C11H16N5O7PS.C6H15N.H2O/c1-25-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(23-10)2-22-24(19,20)21;1-4-7(5-2)6-3;/h3-4,6-7,10,17-18H,2H2,1H3,(H2,12,14,15)(H2,19,20,21);4-6H2,1-3H3;1H2/t4-,6-,7-,10-;;/m1../s1
YQMUWWZKFZERBT-IDIVVRGQSA-N

Categorie correlate

Applicazioni

2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate has been used:

  • as a P2Y12 inhibitor to study its effects on stimulation of endocytosis in high-density lipoprotein (HDL).
  • as a P2Y12 inhibitor to study its effects on platelet recruitment in whole human blood.

Azioni biochim/fisiol

2-Methylthioadenosine5′-monophosphate triethylammonium salt (2-MeSAMP) is an adenosine-based P2Y12 antagonist and ADP-dependent platelet aggregation inhibitory agent.(1) It has a potential to inhibit platelet activation throughP2Y12/G(i)-dependent mechanism.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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Labarthe B, Babin J, Bryckaert M, et al.
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S F Maloney et al.
Integrative biology : quantitative biosciences from nano to macro, 2(4), 183-192 (2010-05-18)
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