K0253
Keratin from human epidermis
aqueous solution
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1 MG
CHF 192.00
5 MG
CHF 699.00
10 MG
CHF 1’200.00
Scegli un formato
Cambia visualizzazione
1 MG
CHF 192.00
5 MG
CHF 699.00
10 MG
CHF 1’200.00
About This Item
Prodotti consigliati
Origine biologica
human epidermis
Saggio
≥90% (SDS-PAGE)
Stato
urea solution
tecniche
ELISA: suitable
N° accesso UniProt
Temperatura di conservazione
2-8°C
Informazioni sul gene
human ... KRT1(3848)
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Descrizione generale
Keratins are characteristic intermediate filament proteins of the epithelia. In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein.[1] The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13.[2] It is the primary component of hair, skin and nails.
Applicazioni
Keratin from human epidermis has been used:
Azioni biochim/fisiol
Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis.[6] This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.[7]
Stato fisico
Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Sens. 1
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Christian Mozet et al.
Anticancer research, 33(6), 2415-2424 (2013-06-12)
The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with
Next-generation sequencing detection and characterization of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma
Banerjee S, et al.
Experimental Dermatology, 24(2), 152-155 (2015)
Francesca Angiero et al.
Anticancer research, 33(6), 2673-2677 (2013-06-12)
The adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin, composed of odontogenic epithelium and characterized by slow but progressive growth. We report a rare case of AOT in an 18-year-old, who presented with a palpable bony-hard swelling
N O Ku et al.
The Journal of cell biology, 143(7), 2023-2032 (1998-12-29)
Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18
Jyh-Hong Lee et al.
Journal of biomedical optics, 14(1), 014008-014008 (2009-03-05)
Atopic dermatitis (AD) is characterized by hyperkeratosis of epidermis and fibrosis within dermis in chronic skin lesions. Thus far, the histology of skin lesions has been evaluated only by examination of excised specimens. A noninvasive in vivo tool is essential
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