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G7879

Sigma-Aldrich

D-Glucose 6-phosphate sodium salt

≥98% (HPLC)

Sinonimo/i:

D(+)-Glucopyranose 6-phosphate sodium salt, G-6-P Na, Robison ester

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500 MG
CHF 116.00
1 G
CHF 187.00
5 G
CHF 666.00
25 G
CHF 2’870.00

CHF 116.00

Spedizione prevista il31 maggio 2025

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Cambia visualizzazione
500 MG
CHF 116.00
1 G
CHF 187.00
5 G
CHF 666.00
25 G
CHF 2’870.00

About This Item

Formula empirica (notazione di Hill):
C6H12NaO9P
Numero CAS:
54010-71-8
Peso molecolare:
282.12
Beilstein:
5787568
Numero CE:
258-921-0
Numero MDL:
MFCD00006611
Codice UNSPSC:
12352201
ID PubChem:
24895324
NACRES:
NA.25

CHF 116.00

Spedizione prevista il31 maggio 2025

Richiedi un ordine bulk

Origine biologica

synthetic (organic)

Livello qualitativo

300

Saggio

≥98% (HPLC)

Stato

crystalline

tecniche

HPLC: suitable

Colore

white

Intervallo di pH utile

4.0-5.0

Punto di fusione

204 °C (dec.) (lit.)

Solubilità

water: 50 mg/mL, clear, colorless to very faintly yellow

Cationi in tracce

Na: 6.1-10.2% (anhydrous)

Temperatura di conservazione

room temp

Stringa SMILE

[Na+].O[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C6H13O9P.Na/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;/h2-10H,1H2,(H2,11,12,13);/q;+1/p-1/t2-,3-,4+,5-,6-;/m1./s1
ZALKNDISPIVVKC-WYRLRVFGSA-M

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Categorie correlate

Applicazioni

D-glucose-6-phosphate sodium can be used as an energy source for Mycobacterium tuberculosis. [1]

Azioni biochim/fisiol

In cells, D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.

Avvertenza

Non-hygroscopic, and very stable to atmospheric moisture at room temperature, unlike the disodium salt.

Altre note

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000436288
0000436270
0000436288
0000436270
0000365994

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Iain J Abbott et al.
Antimicrobial agents and chemotherapy, 64(6) (2020-04-08)
There are limited treatment options for enterococcal urinary tract infections, especially vancomycin-resistant Enterococcus (VRE). Oral fosfomycin is a potential option, although limited data are available guiding dosing and susceptibility. We undertook pharmacodynamic profiling of fosfomycin against E. faecalis and E.
Iain J Abbott et al.
The Journal of antimicrobial chemotherapy, 75(4), 988-996 (2019-12-25)
To assess the antibacterial effects of a single 3 g oral fosfomycin dose on Escherichia coli and Klebsiella pneumoniae clinical isolates within a dynamic bladder infection model. An in vitro model simulating dynamic urinary fosfomycin concentrations was used. Target fosfomycin exposure
Iain J Abbott et al.
Journal of microbiological methods, 171, 105861-105861 (2020-02-09)
The impact of the bladder environment on fosfomycin activity and treatment response is uncertain. Standard laboratory media does not reflect the biomatrix of urine, where limited nutritional factors are important for growth and antimicrobial kill rates. We compared fosfomycin activity
Iain J Abbott et al.
Antimicrobial agents and chemotherapy, 64(3) (2020-01-08)
Oral fosfomycin trometamol is licensed as a single oral dose for the treatment of uncomplicated urinary tract infections, with activity against multidrug-resistant uropathogens. The impact of interindividual variability in urinary concentrations on antimicrobial efficacy, and any benefit of giving multiple
Calvin S Carter et al.
Cell metabolism, 32(4), 561-574 (2020-10-08)
Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic redox homeostasis have had limited success. A noninvasive, sustained approach would enable the long-term control of redox signaling for
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Articoli

Aerobic Glycolysis and the Warburg Effect

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

Protocolli

Enzymatic Activity of Glucose-6-Phosphatase [EC 3.1.3.9]

To measure glucose-6-phosphatase activity, the Taussky-Shorr method is used. This method is a spectrophotometric stop-rate determination assay that is measured at 660 nm.

Enzymatic Assay of Glucose-6-Phosphate Dehydrogenase (EC 1.1.1.49)

To measure glucose-6-phosphate dehydrogenase activity, beta-nicotinamide adenine dinucleotide phosphate is used in a spectrophotometric rate determination assay at 340 nm.

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. May I know what is the recommended storage condition for the reconstituted working solution and the estimated shelf life for both the stock and the working solution?

    1 answer

    1. Unfortunately, the stability of the material in solution at the working concentration has not been determined. However, similar product 346764, α-D-Glucose-6-phosphate monosodium salt, states that aqueous stock solutions are stable for up to 6 weeks at -20°C.

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