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Merck
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Documenti fondamentali

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E0514

Sigma-Aldrich

E-64c

Calpain Inhibitor

Sinonimo/i:

(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane

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About This Item

Formula empirica (notazione di Hill):
C15H26N2O5
Numero CAS:
76684-89-4
Peso molecolare:
314.38
Numero MDL:
MFCD00132882
Codice UNSPSC:
12352202
ID PubChem:
24894369

Origine biologica

synthetic (organic)

Saggio

≥98% (HPLC)

Stato

powder

Solubilità

ethanol: 20 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O

InChI

1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
SCMSYZJDIQPSDI-SRVKXCTJSA-N

Informazioni sul gene

human ... CAPN1(823)

Azioni biochim/fisiol

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor.
Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

Linkage

Synthetic analog of E-64

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
BCBS6258
BCBR7529V
BCBM0550V
BCBR7529
BCBM0550

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Calpain Inhibitor III The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208722

Calpain Inhibitor III

CA-074 methyl ester ≥99% (TLC)

Sigma-Aldrich

C5857

CA-074 methyl ester

Calpeptin ≥98% (HPLC)

Sigma-Aldrich

C8999

Calpeptin

Calpain Inhibitor I N-Acetyl-Leu-Leu-norleucinal, synthetic

Roche

11086090001

Calpain Inhibitor I

Bestatin hydrochloride ≥98% (HPLC)

Sigma-Aldrich

B8385

Bestatin hydrochloride

Pepstatin A microbial, ≥90% (HPLC)

Sigma-Aldrich

P5318

Pepstatin A

Leupeptina microbial, ≥90% (HPLC)

Sigma-Aldrich

L2884

Leupeptina

Chihiro Takatsuka et al.
Plant & cell physiology, 52(12), 2074-2087 (2011-11-01)
Tobacco culture cells carry out a large-scale degradation of intracellular proteins in order to survive under sucrose starvation conditions. We have previously suggested that this bulk degradation of cellular proteins is performed by autophagy, where autolysosomes formed de novo act
Milena Mladenovic et al.
The journal of physical chemistry. B, 113(15), 5072-5082 (2009-03-27)
In the present paper, we investigate whether crystal and enzyme environments influence the electron density (ED) of active compounds in a similar manner. This supposition is essential for high-resolution X-ray studies, which use the EDs obtained from crystals of the
D A Raj et al.
Pflugers Archiv : European journal of physiology, 435(6), 804-809 (1998-06-13)
An inflammatory response triggered by neutrophil accumulation into muscle tissue is thought to occur with exercise-induced muscle damage. To investigate the relationship between Ca2+-stimulated proteolysis (calpain-like activity) and neutrophil accumulation [myeloperoxidase (MPO) activity], cardiac and plantaris muscles from rats (n
K Tsuchiya et al.
Experimental neurology, 155(2), 187-194 (1999-03-11)
This paper is to study the participation of cathepsin in ischemic neuronal death of the monkey hippocampal cornu ammonis (CA) 1 sector and also to clarify whether its selective inhibitor epoxysuccinyl peptides such as CA-074 and E-64c can inhibit the
L B Creemers et al.
Matrix biology : journal of the International Society for Matrix Biology, 16(9), 575-584 (1998-05-06)
The involvement of cysteine proteinases in the degradation of soft connective tissue collagen was studied in cultured periosteal explants. Using cysteine proteinase inhibitors that were active intracellularly or extracellularly (Ep453 and Ep475, respectively), it was shown that over-all collagen degradation
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