E0162
Carboxylesterase 1 isoform c human
recombinant, expressed in baculovirus infected BTI insect cells
Sinonimo/i:
Carboxylesterase 1 human, carboxylesterase, esterase
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1 VIAL
CHF 469.00
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1 VIAL
CHF 469.00
About This Item
CHF 469.00
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Prodotti consigliati
Ricombinante
expressed in baculovirus infected BTI insect cells
Livello qualitativo
Stato
liquid
Concentrazione
≥0.3 mg/mL
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
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Descrizione generale
Applicazioni
Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies.[3] It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies.[4]
Azioni biochim/fisiol
Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin.[2] They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs).[2] It also hydrolyzes aromatic and aliphatic esters[5] with preference to small alcohol groups and bulky acyl groups.[6] CE1 metabolizes drug esters and amides carbamates.[5] It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs.[7]
Proprietà fisiche
This product is offered in a volume of 0.5 mL.
Definizione di unità
One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 °C.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Jihong Lian et al.
Protein & cell, 9(2), 178-195 (2017-07-06)
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro
Carboxylesterases: sources, characterization and broader applications
Sood S, et al.
Insight (American Society of Ophthalmic Registered Nurses), 1, 1-11 (2016)
S Casey Laizure et al.
Pharmacotherapy, 33(2), 210-222 (2013-02-07)
Carboxylesterases are a multigene family of mammalian enzymes widely distributed throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and carbamates. In humans, two carboxylesterases, hCE1 and hCE2, are important mediators of drug metabolism. Both are expressed in
Plasmatic B-esterases as potential biomarkers of exposure to marine plastics in loggerhead turtles.
Sole, et al.
Environmental Research, 213, 113639-113639 (2022)
Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
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