D4505

5,5-Diphenylhydantoin sodium salt

≥99%

• Sinonimo/i: 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Formula condensata: C₁₅H₁₁N₂O₂Na
• Numero CAS: 630-93-3
• Peso molecolare: 274.25
• Numero CE: 211-148-2
• Numero MDL: MFCD00069674
• Codice UNSPSC: 12352200
• ID PubChem: 24277707
• NACRES: NA.77

Proprietà

• Saggio: ≥99%
• Stato: powder
• Solubilità: aqueous base: soluble
• Stringa SMILE: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1; FJPYVLNWWICYDW-UHFFFAOYSA-M
• Informazioni sul gene: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

Descrizione

Descrizione generale

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin.[1] 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors.[2] Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.[3]

Applicazioni

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds[4]
• in seizure behavior testing as an anticonvulsant in Drosophila[5]
• in in vivo embryo toxicity test in mouse embryonic stem cells[6]

Azioni biochim/fisiol

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H317,H361
• Consigli di prudenza: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges