This product is not tested for Nitrosamine content. This product is research use only. Test specifications for this product is listed on the lot-specific Certificate of Analysis. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
https://www.sigmaaldrich.com/product/sigma/a8404#product-documentation
A8404
Amitriptyline hydrochloride
≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
10 g | Per conoscere la disponibilità, visualizza il carrello | CHF 101.00 |
25 g | Per conoscere la disponibilità, visualizza il carrello | CHF 114.00 |
100 g | Per conoscere la disponibilità, visualizza il carrello | CHF 260.00 CHF 221.00 |
250 g | Per conoscere la disponibilità, visualizza il carrello | CHF 437.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C20H23N · HCl
Numero CAS:
Peso molecolare:
313.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-964-6
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
Amitriptyline hydrochloride, ≥98% (TLC), powder
Quality Segment
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: soluble, ethanol: soluble
originator
Bristol-Myers Squibb
storage temp.
2-8°C
SMILES string
Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key
KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)
Application
Amitriptyline hydrochloride has been used:
- as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
- as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
- as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse
Biochem/physiol Actions
Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Features and Benefits
Shelf-life of the powder is at least three years.
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Questo articolo | |||
|---|---|---|---|
| description ≥98% (TLC), powder | description ≥98% (TLC), powder | description ≥98% (TLC), solid | description A mobile ion-carrier that forms stable complexes with divalent cations. |
| assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% (TLC) |
| form powder | form powder | form solid | form solid |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| solubility ethanol: soluble, H2O: soluble | solubility ethanol: soluble, H2O: soluble | solubility ethanol: soluble, methanol: soluble | solubility methanol: soluble, DMSO: soluble |
| originator Bristol-Myers Squibb | originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
Classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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