Product C2759 has not undergone cell culture testing. However, information about storage after reconstitution is available. It states, "Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C."
C2759
Carbonyl Cyanide m-Chlorophenylhydrazone
≥97% (TLC), powder, mitophagy inducer
Sinonimo/i:
m-Cl-CCP, CCCP, Mesoxalonitrile 3-chlorophenylhydrazone
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100 MG
CHF 48.00
250 MG
CHF 139.00
1 G
CHF 275.00
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Cambia visualizzazione
100 MG
CHF 48.00
250 MG
CHF 139.00
1 G
CHF 275.00
About This Item
Formula empirica (notazione di Hill):
C9H5ClN4
Numero CAS:
Peso molecolare:
204.62
Beilstein:
1842102
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Carbonyl cyanide 3-chlorophenylhydrazone, ≥97% (TLC), powder
Livello qualitativo
Saggio
≥97% (TLC)
Stato
powder
Colore
yellow to orange
Solubilità
DMSO: 100 mM
Temperatura di conservazione
−20°C
Stringa SMILE
Clc1cccc(N\N=C(\C#N)C#N)c1
InChI
1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
UGTJLJZQQFGTJD-UHFFFAOYSA-N
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Applicazioni
Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:
- in the inhibition of efflux pump in clinical Pseudomonas aeruginosa[1]
- to inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cells[2]
- to prepare carbonyl cyanide m-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans[3]
Azioni biochim/fisiol
Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induces mitophagy in mammalian cells.[3] CCCP suppresses the expression of few electron transport chain (ETC) proteins.[2] Protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. Shown to have a number of effects on cellular calcium. Inhibits secretion of hepatic lipase and partially inhibits the pH gradient-activated Cl- uptake and Cl-/Cl- exchange activities in brush-border membrane vesicles.
Avvertenze
Danger
Indicazioni di pericolo
Classi di pericolo
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Articoli
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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