C1480

Z-Phe-Ala fluoromethyl ketone

≥90% (TLC), powder

• Sinonimo/i: Z-FA-FMK
• Formula condensata: C₂₁H₂₃N₂O₄F
• Peso molecolare: 386.42
• Numero MDL: MFCD00883668
• Codice UNSPSC: 12352209
• ID PubChem: 329774889
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥90% (TLC)
• Stato: powder
• Colore: white to off-white
• Solubilità: DMSO or DMF: 20 mM
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1; ASXVEBPEZMSPHB-YJBOKZPZSA-N

Descrizione

Applicazioni

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:

• cathepsin inhibitor to study its effects on dendritic cells[1]
• papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis[2]
• cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages[3]

Azioni biochim/fisiol

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L.[4][5] It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10.[4] Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation.[5] It exhibits therapeutic effects against rheumatoid arthritis.[5]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)