This product has not been validated for cell-based experiments. However, literature indicates that it has been used successfully in cell-based experiments. For more information, please see references provided on the product web page. https://www.sigmaaldrich.com/en/product/sigma/e3520
E3520
Ebselen
powder, ≥98% (TLC)
Sinonimo/i:
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Scegli un formato
Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 248.00 |
100 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 752.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C13H9NOSe
Numero CAS:
Peso molecolare:
274.18
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartiNome del prodotto
Ebselen, cysteine modifier
Quality Segment
assay
≥98% (TLC)
form
powder
mp
176-182 °C
solubility
chloroform: 19.60-20.40 mg/mL, clear, yellow
storage temp.
2-8°C
SMILES string
O=C1N([Se]c2ccccc12)c3ccccc3
InChI
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChI key
DYEFUKCXAQOFHX-UHFFFAOYSA-N
General description
Ebselen is a sympathomimetic amine.
Application
Ebselen has been used as a:
extensor digitorum longus (fast-twitch) muscle
- voltage-dependent calcium channels (VDCCs) blocker[1]
- glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse
extensor digitorum longus (fast-twitch) muscle
- glucocerebrosidase inhibitor
- hepatitis C virus helicase inhibitor[2]
Biochem/physiol Actions
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.
An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol.[3] Inhibits oxidation of low density lipoproteins (LDL).
1 of 1
Questo articolo | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder | form powder | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility chloroform: 19.60-20.40 mg/mL, clear, yellow | solubility DMSO: 5 mg/mL (clear solution) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| mp 176-182 °C | mp - | mp - | mp - |
Still not finding the right product?
Explore all of our products under Ebselen
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
Classe di stoccaggio
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
-
Hello, we recently ordered this product (Ebselen, Cat# E3520). I dissolved it in DMSO (5 mg/mL) and plan to use it in cell experiments. However, I just noticed that the purity is ≥98% (TLC). Would this be suitable for cell-based experiments.Thank you.
1 answer-
Helpful?
-