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Merck
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Key Documents

AV100871

Sigma-Aldrich

Anti-TCF3 (AB2) antibody produced in rabbit

IgG fraction of antiserum

Sinonimo/i:

Anti-E2A, Anti-ITF1, Anti-MGC129647, Anti-MGC129648, Anti-Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

48 kDa

Reattività contro le specie

mouse, dog, guinea pig, human, rat

Concentrazione

0.5 mg - 1 mg/mL

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TCF3(6929)

Immunogeno

Synthetic peptide directed towards the C terminal region of human TCF3

Applicazioni

Anti-TCF3 antibody produced in rabbit is suitable for western blotting at a concentration of 5 μg/ml.

Azioni biochim/fisiol

TCF3 belongs to the E-protein (class I) family of transcription factors and is an important regulator of B and T lymphocyte development, tumor growth and progression. TCF3 modulates the Wnt-mediated signaling and regulates osteogenesis and neural differentiation.

Sequenza

Synthetic peptide located within the following region: EENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPPEQKAEREKERRVAN

Stato fisico

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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W Liu et al.
Cell death & disease, 4, e539-e539 (2013-03-16)
Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the
Michal Slyper et al.
Cancer research, 72(21), 5613-5624 (2012-10-24)
Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a member of the TCF/LEF transcription factor family that is central
Yaser Atlasi et al.
PLoS genetics, 9(5), e1003424-e1003424 (2013-05-10)
Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and

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