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Documenti fondamentali

A9950

Sigma-Aldrich

Aniracetam

≥98%

Sinonimo/i:

1-(4-Methoxybenzoyl)-2-pyrrolidinone, Ro 13-5057

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About This Item

Formula empirica (notazione di Hill):
C12H13NO3
Numero CAS:
Peso molecolare:
219.24
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77

Saggio

≥98%

Ideatore

Roche

Stringa SMILE

COc1ccc(cc1)C(=O)N2CCCC2=O

InChI

1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
ZXNRTKGTQJPIJK-UHFFFAOYSA-N

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Applicazioni

Aniracetam has been used in the inhibition screening assays for kinase enzyme.[1]

Azioni biochim/fisiol

Aniracetam is a piracetam analog and has low bioavailability due to rapid excretion.[2] It enhances the cognitive thinking and is effective for treatment of sleep and behavioral disorders.[3] Aniracetam is prescribed for anxiety and also enhances learning and memory in situations with induced damage of the brain.[4]
Cognition enhancer (nootropic) that potentiates AMPA receptor mediated ion conductance and potentiates metabotropic glutamate receptor activity.

Caratteristiche e vantaggi

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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    Dementia constitutes an increasingly prevalent cognitive disorder with serious socioeconomic implications. In the present study, we aimed to evaluate the efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors (ChEIs), in terms of several neuropsychological parameters, in a
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    CNS drug reviews, 8(1), 70-89 (2002-06-19)
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    Julia Vaglenova et al.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 33(5), 1071-1083 (2007-07-05)
    Specific pharmacological treatments are currently not available to address problems resulting from fetal ethanol exposure, described as Fetal Alcohol Syndrome or Fetal Alcohol Spectrum Disorders (FASD). The present study evaluated the therapeutic effects of aniracetam against cognitive deficits in a
    Rudolf Mueller et al.
    Bioorganic & medicinal chemistry letters, 21(13), 3927-3930 (2011-06-04)
    AMPA receptors (AMPARs) are an important therapeutic target in the CNS. A series of substituted benzoxazinone derivatives with good to very good in vitro activity as positive allosteric AMPAR modulators was synthesized and evaluated. The appropriate substituent choice on the

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