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A4108

Sigma-Aldrich

Aminophenyl fluorescein solution

5 mM in DMF, suitable for fluorescence

Sinonimo/i:

2-[6-(4′-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid solution, APF solution

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1 MG
CHF 938.00

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1 MG
CHF 938.00

About This Item

Numero CE:
200-679-5
Codice UNSPSC:
12352108
NACRES:
NA.32

CHF 938.00

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Stato

liquid

Concentrazione

5 mM in DMF

Compatibilità

suitable for fluorescence

Temperatura di conservazione

2-8°C

Categorie correlate

Descrizione generale

Aminophenyl fluorescein solution, also known as APF, is a novel fluorescent probe. APF exists as a non-fluorescent entity, which converts to its fluorescent form called fluorescein upon oxidation. The excitation length is at 488nm, and the emission spectrum is monitored between 495-600nm and measured using flow cytometry.[1]

Fluorescence intensity increases after reaction with hROS (e.g. hydroxy radical, peroxynitrite and hypochlorite). And, APF is resistant to light-induced autoxidation.

Applicazioni

Aminophenyl fluorescein solution is a suitable tool to detect hypobromous acid (HOBr) produced in eosinophils. It is used to detect the halogenating activity of heme peroxidases in leukocytes. [2] APF does not react with nitric oxide, superoxide, and hydrogen peroxide; hence, it can be used to detect peroxynitrite differentially.
Fluorescent detector of highly reactive oxygen species (hROS). Fluorescence intensity increases after reaction with hROS (e.g. hydroxy radical, peroxynitrite and hypochlorite). Since APF does not react with nitric oxide, superoxide, and hydrogen peroxide, it can be used to differentially detect peroxynitrite. APF is resistant to light-induced autoxidation.

Avvertenze

Danger

Indicazioni di pericolo

H226,H312 + H332,H319,H360D

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

135.5 °F - closed cup

Punto d’infiammabilità (°C)

57.5 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
0000387683
0000387683
0000288616
0000288616
SLCR3625

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J Flemmig et al.
Free radical research, 49(6), 768-776 (2014-12-24)
The formation of hypochlorous and hypobromous acids by heme peroxidases is a key property of certain immune cells. These products are not only involved in defense against pathogenic microorganisms and in regulation of inflammatory processes, but contribute also to tissue
Jörg Flemmig et al.
The Journal of biological chemistry, 287(33), 27913-27923 (2012-06-22)
The specific detection of peroxidase activity in human granulocytes is essential to elucidate their role in innate immune responses, immune regulation, and inflammatory diseases. The halogenating activity of myeloperoxidase in neutrophils can be determined by the novel fluorescent probe aminophenyl

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