Yes, yeasts are eukaryotic organisms. α-Amanitin inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase.
A2263
α-Amanitin
from Amanita phalloides, ≥85% (HPLC), powder
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Cambia visualizzazione
1 MG
CHF 361.00
About This Item
Formula empirica (notazione di Hill):
C39H54N10O14S
Numero CAS:
Peso molecolare:
918.97
Beilstein:
1071138
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
NACRES:
NA.32
Prodotti consigliati
Origine biologica
Amanita phalloides
Livello qualitativo
Saggio
≥85% (HPLC)
Stato
powder
PM
918.97 g/mol
Colore
white to light yellow
Punto di fusione
254-255 °C (lit.)
Solubilità
H2O: 1.0 mg/mL
ε (coefficiente d’estinzione)
13,500 at 310 nm in H2O at 1 M
Temperatura di conservazione
−20°C
Stringa SMILE
CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2
InChI
1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)
CIORWBWIBBPXCG-UHFFFAOYSA-N
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Amino Acid Sequence
Asn-Hyp-Hyi-Trp-Gly-Ile-Gly-Cys [Bridge: 4-8]
Applicazioni
Azioni biochim/fisiol
Inhibits eukaryotic RNA polymerase II and III; does not inhibit RNA polymerase I or bacterial RNA polymerase; inhibits mammalian protein synthesis.
The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
Avvertenza
When stored frozen in the dark, retained samples were found to be greater than 99% by HPLC after two years.
Ricostituzione
Store a 1 mg/ml aqueous stock solution frozen at -20°C. It does not degrade with repeated freeze-thaw cycles. Dilute into the appropriate buffer immediately prior to use. Product is destroyed by concentrated acid or base.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 1 Oral - STOT RE 2
Organi bersaglio
Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system
Codice della classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 3
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Can we use this product (alpha amanitin: A2263) to block RNA PII for yeast cell (S. cerevisiae)?
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