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C0166000

Calcifediol

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

25-Hydroxyvitamin D3 monohydrate, 25-Hydroxycholecalciferol

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About This Item

Formula empirica (notazione di Hill):
C27H44O2 · H2O
Numero CAS:
63283-36-3
Peso molecolare:
418.65
Beilstein:
4270041
Numero MDL:
MFCD00867077
Codice UNSPSC:
41116107
ID PubChem:
329774765
NACRES:
NA.24

Origine biologica

sheep wool (grease)

Grado

pharmaceutical primary standard

agenzia

EP

Famiglia di API

calcifediol

Stato

solid

Produttore/marchio commerciale

EDQM

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
JWUBBDSIWDLEOM-DTOXIADCSA-N

Informazioni sul gene

human ... VDR(7421)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.Calcifediol is a biologically active metabolite of vitamin D. It is more hydrophilic and better absorbed in the intestine when compared to ergocalciferol or cholecalciferol due to the high affinity for the vitamin-D-binding protein. The drug is known to treat diseases associated with decreased intestinal absorption and obesity.

Applicazioni

Calcifediol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Prodotti correlati

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Determinazione del prezzo

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311,H330,H372

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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25-Hydroxyvitamin D calibration solutions NIST® SRM® 2972a

NIST2972A

25-Hydroxyvitamin D calibration solutions

25-Hydroxyvitamin D3 solution 100 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

H-083

25-Hydroxyvitamin D3 solution

USP

USP

1086301

Calcitriol

Colecalciferolo (D3) analytical standard

Supelco

47763

Colecalciferolo (D3)

1α,25-diidrossivitamina D3 ≥99% (HPLC)

Sigma-Aldrich

D1530

1α,25-diidrossivitamina D3

Colecalciferolo ≥98% (HPLC)

Sigma-Aldrich

C9756

Colecalciferolo

Ergocalciferol ≥98.0% (sum of enantiomers, HPLC)

Sigma-Aldrich

95220

Ergocalciferol

Hypovitaminosis D: is it time to consider the use of calcifediol?
Cesareo R, et al.
Nutrients, 11(5), 1016-1016 (2019)
Johanna Breuer et al.
Annals of neurology, 75(5), 739-758 (2014-04-29)
Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple sclerosis (MS). Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate
Ting-I Lee et al.
International journal of cardiology, 176(1), 151-157 (2014-07-27)
High free fatty acid with reduced glucose utilization in diabetes mellitus (DM) impairs cardiac function. Peroxisome proliferator-activated receptors (PPARs) modulate myocardial lipid and glucose homeostasis. The active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates oxidative stress and inflammation, which may play a key
Stuart M Sprague et al.
American journal of nephrology, 40(6), 535-545 (2015-01-13)
Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D
Kristyna Brabnikova-Maresova et al.
Arthritis research & therapy, 16(5), 460-460 (2014-10-05)
Juvenile idiopathic arthritis (JIA) is a disease associated with loss of bone mass, deterioration in bone mass quality and an increased risk of fractures. The objective of this study was to evaluate factors that predict bone mineral density (BMD) alterations
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