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C9756

Sigma-Aldrich

Colecalciferolo

≥98% (HPLC)

Sinonimo/i:

(+)-Vitamina D3, 7-deidrocolesterolo attivato, Calciol

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1 G
CHF 95.60
5 G
CHF 413.00

CHF 95.60

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1 G
CHF 95.60
5 G
CHF 413.00

About This Item

Formula empirica (notazione di Hill):
C27H44O
Numero CAS:
67-97-0
Peso molecolare:
384.64
Beilstein:
2339331
Numero CE:
200-673-2
Numero MDL:
MFCD00078131
Codice UNSPSC:
12352209
eCl@ss:
34058003
ID PubChem:
24893192
NACRES:
NA.26

CHF 95.60

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Origine biologica

synthetic (organic)

Saggio

≥98% (HPLC)

Stato

powder

tecniche

HPLC: suitable

Colore

white to off-white

Punto di fusione

83-86 °C (lit.)

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
QYSXJUFSXHHAJI-YRZJJWOYSA-N

Informazioni sul gene

human ... VDR(7421)

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Categorie correlate

Descrizione generale

Cholecalciferol acts as a hormone precursor since it requires two stages of metabolism: first to 25-hydroxycholecalciferol; then to 1α, 25-dihydroxycholecalciferol. One unit (U.S.P. or international) is defined as the activity of 0.025 μg of vitamin D3 contained in the USP vitamin D reference standard.
Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue.[1]

Applicazioni


  • Alterations in regulators of the renal-bone axis, inflammation and iron status in older people with early renal impairment and the effect of vitamin D supplementation.: This study delves into the significant roles of cholecalciferol in modulating the renal-bone axis, inflammatory responses, and iron metabolism in elderly patients with renal impairment. Through vitamin D supplementation, researchers observed pivotal changes that could guide future therapeutic strategies (Christodoulou M et al., 2024).

  • Investigating the effects of 25-hydroxyvitamin D3 on clinical outcomes in multiple sclerosis patients: A randomized, double-blind clinical trial- a pilot study.: This clinical trial assesses the efficacy of cholecalciferol in improving the health outcomes of patients with multiple sclerosis. The use of cholecalciferol potentially enhances neurological function and reduces disease progression, illustrating its vital role in neurodegenerative disease management (Maghbooli Z et al., 2024).

  • Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway.: This pivotal research links cholecalciferol to the reduction of COVID-19 severity through its regulatory effects on the NLRP3 inflammasome pathway. The findings underscore the potential of vitamin D as a modulatory agent in the immune response against viral infections (Khalil B et al., 2024).

  • Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System in Obese or Overweight Individuals.: This randomized controlled trial explores how cholecalciferol supplementation can affect cardiovascular and autonomic functions in obese or overweight patients, providing insights into its benefits beyond bone health and into cardiovascular regulation (Faria ACC et al., 2024).


Azioni biochim/fisiol

La vitamina D agisce attraverso un recettore che modula la proliferazione e la differenziazione delle cellule sia normali, sia tumorali.
La vitamina D agisce attraverso un recettore che è un membro della superfamiglia dei fattori di trascrizione ligando-dipendenti. Modula la proliferazione e la differenziazione sia delle cellule normali che tumorali. Ha effetti antiproliferativi e antimetastatici sulle cellule del cancro della mammella, del colon e della prostata. I recettori della vitamina D attivati nell'intestino e nelle ossa sono responsabili della regolazione dell'assorbimento e dell'omeostasi del calcio.
Deficiency of vitamin D is often observed in chronic kidney disease.[2]

Stoccaggio e stabilità

Cholecalciferol C9756 is packaged under argon gas. If it is stored unopened at 2-8°C and protected from light, this product should be stable for a minimum of three years. Unused portions should be stored under nitrogen or argon gas. Deterioration is negligible after storage of one year in amber-evaculated ampules at refrigerator temperatures. It is oxidized and inactivated by moist air within a few days.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330,H372

Classi di pericolo

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000406067
0000406065
0000402824
0000402825
0000390858

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Slide 1 of 6

1 of 6

Colecalciferolo British Pharmacopoeia (BP) Reference Standard

BP787

Colecalciferolo

25-Hydroxycholecalciferol ≥98% (HPLC)

Sigma-Aldrich

H4014

25-Hydroxycholecalciferol

Vitamina D₃ (colecalciferolo) crist. (1 g = 40 Mio U.I.) EMPROVE® ESSENTIAL, Ph. Eur., BP, USP

SAFC

5.00936

Vitamina D₃ (colecalciferolo) crist. (1 g = 40 Mio U.I.)

25-Hydroxyvitamin D3 monohydrate ≥99.0% (HPLC)

Sigma-Aldrich

17938

25-Hydroxyvitamin D3 monohydrate

Vitamin D3 solution 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-025

Vitamin D3 solution

7-Dehydrocholesterol ≥95.0% (HPLC)

Sigma-Aldrich

30800

7-Dehydrocholesterol

Clinical Veterinary Toxicology, 448-448 (2003)
Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters
Matias P, et al.
Clinical journal of the American Society of Nephrology : CJASN, CJN-06510909 (2010)
Lin Fu et al.
Journal of immunology (Baltimore, Md. : 1950), 203(5), 1198-1207 (2019-07-19)
It is increasingly recognized that excessive glucocorticoids induce fetal intrauterine growth restriction (IUGR). Placental 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), a glucocorticoid-catalyzing enzyme, prevents active glucocorticoids from maternal circulation into the fetus, thus protecting against IUGR. Previous studies demonstrated gestational LPS exposure
Stefan Pilz et al.
Hypertension (Dallas, Tex. : 1979), 65(6), 1195-1201 (2015-03-25)
Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values
Patricia Fernandez-Robredo et al.
Antioxidants (Basel, Switzerland), 9(9) (2020-09-12)
Diabetic retinopathy is a vision-threatening microvascular complication of diabetes and is one of the leading causes of blindness. Oxidative stress and inflammation play a major role in its pathogenesis, and new therapies counteracting these contributors could be of great interest.
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Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Hi Please advise how to make retest for your products C9756-5G Regards

    1 answer

    1. Products are retested according to the schedule set by Quality guidelines. In the case of C9756, the retest occurs every 3 years. Retesting only occurs if ample stock is available of the specific lot. Product retesting is not performed if the batch has sold out, nor is retesting performed upon request. Should stock remain, retesting will be performed near the assigned retest date. Should the lot continue to meet all specifications, the lot retest date is extended and an updated Certificate of Analysis will be generated.

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  4. Dear Sirs, could you please advise the CRM for your product C9756 Lot.No. SLCK8275 and advise the associated uncertainty . Regards

    1 answer

    1. Product PHR1237 is offered as a Certified Reference Material. The product C9756 is not a Certified Reference Material nor is it tested against a CRM. It is intended for research use only. Items that are Certified Reference Materials will be clearly stated as such in the product title as well as the in the "Properties" section.

      Helpful?

  5. I am a professor and researcher from an university in Turkey. We bought your C9756 product for cell culture use. How can we resolve and dilute the product (C9756) for cell culture? Thanks for your help

    1 answer

    1. This material has not been tested in a cell culture application. However, the material can be dissolved in 50 mg/ml of ethanol as mentioned on the Certificate of Analysis.

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