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Merck
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Documenti

M74253

Sigma-Aldrich

N-Methyl-N-propargylbenzylamine

97%

Sinonimo/i:

Pargyline

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About This Item

Formula condensata:
C6H5CH2N(CH3)CH2C≡CH
Numero CAS:
555-57-7
Peso molecolare:
159.23
Numero CE:
209-101-6
Numero MDL:
MFCD00008576
Codice UNSPSC:
12352100
ID PubChem:
24897164
NACRES:
NA.22

Saggio

97%

Forma fisica

liquid

Indice di rifrazione

n20/D 1.522 (lit.)

P. eboll.

86-88 °C/4 mmHg (lit.)

Densità

0.944 g/mL at 25 °C (lit.)

Stringa SMILE

CN(CC#C)Cc1ccccc1

InChI

1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3
DPWPWRLQFGFJFI-UHFFFAOYSA-N

Informazioni sul gene

human ... MAOA(4128) , MAOB(4129)

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311 + H331,H315,H319,H335

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

183.2 °F - closed cup

Punto d’infiammabilità (°C)

84 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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Sergiy Konovalov et al.
Journal of ovarian research, 6(1), 75-75 (2013-10-30)
Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription. LSD1 is overexpressed in several cancer types, and
Masahiro Yoshida et al.
The Journal of organic chemistry, 78(4), 1687-1692 (2013-02-01)
The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.
Shauna N Vasilatos et al.
Carcinogenesis, 34(6), 1196-1207 (2013-01-29)
Our previous studies demonstrated that lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) closely interact in controlling growth of breast cancer cells. However, the underlying mechanisms are largely unknown. In this study, we showed that knockdown of LSD1 expression (LSD1-KD)
Gangadhara R Sareddy et al.
Oncotarget, 4(1), 18-28 (2012-12-19)
Glioma development is a multistep process, involving alterations in genetic and epigenetic mechanisms. Understanding the mechanisms and enzymes that promote epigenetic changes in gliomas are urgently needed to identify novel therapeutic targets. We examined the role of histone demethylase KDM1
Avanashiappan Nandakumar et al.
Organic letters, 15(2), 382-385 (2013-01-12)
Tetrasubstituted olefin based new xanthene derivatives have been synthesized via palladium-catalyzed carbopalladation/C-H activation of 2-bromobenzyl-N-propargylamine derivatives. The synthesized compounds display a pronounced solid state fluorescence due to their restricted internal rotation of a C-Ar bond in the solid or aggregation
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