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379409

Sigma-Aldrich

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

98%

Sinonimo/i:

Deferiprone

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CHF 69.70
25 G
CHF 211.00

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5 G
CHF 69.70
25 G
CHF 211.00

About This Item

Formula empirica (notazione di Hill):
C7H9NO2
Numero CAS:
30652-11-0
Peso molecolare:
139.15
Numero MDL:
MFCD00134497
Codice UNSPSC:
12352100
ID PubChem:
24863630
NACRES:
NA.22

CHF 69.70

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Saggio

98%

Stato

powder

Punto di fusione

272-275 °C (lit.)

Gruppo funzionale

ketone

Stringa SMILE

CN1C=CC(=O)C(O)=C1C

InChI

1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
TZXKOCQBRNJULO-UHFFFAOYSA-N

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Descrizione generale

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative. It reacts with uranyl salts [UO2(NO3)2] in aqueous acidic solution to afford mono nuclear complexes ([UO2(dpp)(Hdpp)2(H2O)]ClO4). X-ray studies have been conducted to examine the structure and geometry of these complexes.[1]

Applicazioni

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (OH-pyridone) may be used in the bacterial killing assays.[2] It has been employed as hydroxyketone chelating agent and its cytotoxic action against oral human normal and tumor cell lines has been evaluated.[3]

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Consigli di prudenza

P301 + P312 + P330

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
STBL1267
STBL1268
STBK5488
STBJ7316
STBJ3298

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3-Hydroxy-2-methyl-4-pyrone 99%

Sigma-Aldrich

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Chlorobimane

Sigma-Aldrich

C4528

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Ciclopirox ≥98% (HPLC)

Sigma-Aldrich

SML2011

Ciclopirox

5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one for synthesis

Sigma-Aldrich

8.18461

5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one

N-Methyl-2-pyridone ≥99%

Sigma-Aldrich

M78259

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Iron Chelator IV, 21H7 The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.

Millipore

681679-M

Iron Chelator IV, 21H7

Etheresia Pretorius et al.
Toxicology mechanisms and methods, 23(5), 352-359 (2013-01-03)
Inflammatory diseases associated with iron overload are characterized by a changed coagulation profile, where there is a persistent presence of fibrin-like material of dense-matted deposits (DMDs). It is believed that one source of such material is a result of the
Chryssoula Drouza et al.
Inorganic chemistry, 43(26), 8336-8345 (2004-12-21)
Reaction of [UO(2)(NO(3))(2)] with the hydroxy ketones 3-hydroxy-2-methyl-4-pyrone (Hma) and 3-hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp) in aqueous acidic solutions (pH approximately 3) yields the compounds [UO(2)(ma)(2)(H(2)O)].H(2)O (1.H(2)O) and [UO(2)(dpp)(Hdpp)(2)(H(2)O)]ClO(4) (2), respectively. X-ray diffraction shows that the geometry around the metal ion in both
Eiji Yasumoto et al.
Anticancer research, 24(2B), 755-762 (2004-05-27)
Hydroxyketone chelators, deferiprone (HK1), maltol (HK3) and their related compounds (HK2, 4-8), were characterized for their cytotoxic profiles against oral human normal and tumor cells. Most hydroxyketones except HK6 showed relatively higher tumor-specific cytotoxicity. Deferiprone (HK1), which showed the highest
Jaroslav Cermak et al.
Leukemia research, 37(12), 1612-1615 (2013-08-14)
One hundred thirteen patients with myelodysplastic syndromes (MDS) with <10% of bone marrow blasts received either deferiprone in a daily dose of 40-90 mg/kg (48 patients) or deferasirox in a daily dose of 10-40 mg/kg (65 patients). Median duration of
Raffaella Origa et al.
British journal of haematology, 163(3), 400-403 (2013-09-17)
This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in
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Questions

1–2 of 2 Questions  

  1. What is the suggested solvent and what is the solubility of Deferiprone? Can Deferiprone solution be stored and at which temperature?

    1 answer

    1. This product is soluble in methanol at 5mg/ml. It is not recommended to store aqueous solutions. It is recommended to use freshly prepared solutions.

      Helpful?

  2. What is the recommended storage temperature?

    1 answer

    1. This product is stored at room temperature.

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