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Merck
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284629

Sigma-Aldrich

Amitriptyline hydrochloride

99%

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About This Item

Formula empirica (notazione di Hill):
C20H23N · HCl
Numero CAS:
549-18-8
Peso molecolare:
313.86
Numero CE:
208-964-6
Numero MDL:
MFCD00012537
Codice UNSPSC:
12352103
ID PubChem:
329753201

Saggio

99%

Stringa SMILE

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
KFYRPLNVJVHZGT-UHFFFAOYSA-N

Informazioni sul gene

human ... SLC6A2(6530) , SLC6A4(6532)

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Azioni biochim/fisiol

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Sostituito da

N° Catalogo
Descrizione
Determinazione del prezzo

Avvertenze

Danger

Indicazioni di pericolo

H301,H319,H361d,H410

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
01026LV
11524CG
06505KR
03925MN
02216AM

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S M Lee et al.
International journal of cardiology, 190, 353-359 (2015-05-06)
Amitriptyline (AMY) is a tricyclic anti-depressant that has recently been shown to have anti-inflammatory properties. We investigated whether AMY is cardioprotective against reperfusion injury in ex-vivo rat hearts. Thirty adult Sprague-Dawley rat hearts were perfused ex-vivo in a Langendorff apparatus.
Christian Janfelt et al.
Journal of mass spectrometry : JMS, 48(3), 361-366 (2013-03-16)
Displaced dual-mode imaging (DDI) is introduced as a method for simultaneous imaging in positive and negative-ion mode on the same sample with desorption electrospray ionization imaging, as well as a method for simultaneous imaging in full-scan and tandem mass spectrometry
Juho A Heinonen et al.
Basic & clinical pharmacology & toxicology, 113(3), 193-200 (2013-05-04)
Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after
Scott W Powers et al.
JAMA, 310(24), 2622-2630 (2013-12-26)
Early, safe, effective, and durable evidence-based interventions for children and adolescents with chronic migraine do not exist. To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline. A randomized clinical trial of
Pascal Vanelderen et al.
Regional anesthesia and pain medicine, 38(2), 124-130 (2013-01-23)
In animal models of neuropathic pain (NP), promising results have been reported with the administration of minocycline, possibly through inhibition of spinal brain-derived neurotrophic factor (BDNF) expression. No data are available on the effect of amitriptyline and gabapentin on spinal
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