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Merck

HTR1B

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

Sinonimi:
5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Specie:
Human HTR1B (3351), Mouse Htr1b (15551), Rat Htr1b (25075), chicken HTR1B (421858), Zebrafish htr1b (561647), dog HTR1B (403741), cow HTR1B (317707), Horse HTR1B (100009680), domestic cat HTR1B (100144391), Domestic Rabbit HTR1B (100009594) ...Più
ID UniProtKB:
P28222, Q4VAY7
ID gene:
  • Human(3351) Summary: The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]
  • Mouse(15551) 5-hydroxytryptamine (serotonin) receptor 1B
  • Rat(25075) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • chicken(421858) 5-hydroxytryptamine (serotonin) receptor 1B
  • Zebrafish(561647) 5-hydroxytryptamine (serotonin) receptor 1B
  • dog(403741) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • cow(317707) 5-hydroxytryptamine (serotonin) receptor 1B
  • Horse(100009680) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • domestic cat(100144391) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • Domestic Rabbit(100009594) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • sheep(101111375) 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • domestic guinea pig(100135543) 5-hydroxytryptamine (serotonin) receptor 1B

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
S1198
Sumatriptan succinate, ≥98% (HPLC), solid,
Specie
human
SML0248
Zolmitriptan, ≥98% (HPLC),
Specie
human
1642201
Sumatriptan succinate, United States Pharmacopeia (USP) Reference Standard,
Specie
human
1457469
Naratriptan hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human
1286413
Frovatriptan succinate, United States Pharmacopeia (USP) Reference Standard,
Specie
human

Small Molecule - Allosteric Modulator

N° Catalogo
Descrizione
Specie
D9190
DCEBIO, ≥98% (HPLC), solid,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
M149
Methiothepin mesylate salt, ≥98% (HPLC), solid,
Specie
human
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Specie
human
P8688
(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder,
Specie
human
M137
Methysergide maleate salt, solid,
Specie
human
M3668
Metergoline, ,
Specie
human, rat

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
SAB4501470
Anti-5-HT-1B antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
immunohistochemistry
SAB4501471
Anti-HTR1B antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
western blot
SAB2500924
Anti-Serotonin Receptor 1B/HTR1B antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
canine, human, mouse, rat
Applicazione
ELISA
western blot

Small Molecule - Blocker

N° Catalogo
Descrizione
Specie
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Specie
human
P8688
(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder,
Specie
human
T3146
Trimipramine maleate salt, ≥98% (TLC), powder,
Specie
human
Z101
Zimelidine dihydrochloride, solid,
Specie
human

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Specie
human
F1553
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Specie
human
F1678
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Specie
human
F132
Fluoxetine hydrochloride, solid,
Specie
human
S6319
Sertraline hydrochloride, ≥98% (HPLC),
Specie
human

Small Molecule - Ligand

N° Catalogo
Descrizione
Specie
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Specie
human

Small Molecule - Metabolite

N° Catalogo
Descrizione
Specie
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Specie
human

Small Molecule - Precursor

N° Catalogo
Descrizione
Specie
H9772
5-Hydroxy-L-tryptophan, powder,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EMU044151
MISSION® esiRNA, targeting mouse Htr1b,
Specie
mouse