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M137

Methysergide maleate salt

Name: Methysergide maleate salt
Brand: SIGMA
Price: 143 CHF

solid

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Taglio della confezione	SKU	Disponibilità	Prezzo
2 mg		Per conoscere la disponibilità, visualizza il carrello	CHF 143.00
10 mg		Per conoscere la disponibilità, visualizza il carrello	CHF 288.00 CHF 244.80

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₁H₂₇N₃O₂ · C₄H₄O₄

Numero CAS:

129-49-7

Peso molecolare:

469.53

NACRES:

NA.77

PubChem Substance ID:

24278129

UNSPSC Code:

12352200

EC Number:

204-950-9

MDL number:

MFCD00083185

Form:

solid

CHF 143.00

Per conoscere la disponibilità, visualizza il carrello

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Servizio Tecnico

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Proprietà

form

solid

Quality Segment

100

color

white to off-white

solubility

DMSO: >10 mg/mL, H₂O: 2 mg/mL

originator

Novartis

SMILES string

OC(=O)\C=C/C(O)=O.[H][C@@]12Cc3cn(C)c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO)c34

InChI

1S/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1

InChI key

LWYXFDXUMVEZKS-ZVFOLQIPSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)

Descrizione

Application

Methysergide maleate salt has been used as a serotonin (5HT) receptor antagonist to evaluate the potential systemic effects of methysergide (METH) and 5-HT infusions on production and milk composition in multiparous Holstein cows.[1] It may also be used as a serotonin receptor blocker to identify the serotonergic receptor type involved in the direct excitation of mitral cells in the main olfactory bulb.[2]

Biochem/physiol Actions

Methysergide maleate, also known as sansert,[3] is a semisynthetic ergot alkaloid ergometrine derivative.[4] Methysergide is a serotonin 1(5-HT1) receptor agonist and a nonselective 5-HT2 and 5-HT7 serotonin receptor antagonist.[1][2] Methysergide maleate is used as a pharmacological agent to treat migraines and other vascular headaches. But, prolonged and uncontrolled use of this drug may cause Leriche′s syndrome, angina pectoris, acute ischemia of the limbs. In addition, gastrointestinal side effects, such as abdominal cramps, nausea, and diarrhea have also been observed in few patients.[5]

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo	U115	T123	C231
Sigma-Aldrich M137 Methysergide maleate salt	Sigma-Aldrich U115 U-101958 maleate salt	Sigma-Aldrich T123 Thioperamide maleate salt	Sigma-Aldrich C231 CGP-20712A methanesulfonate salt
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level -	Quality Level 200	Quality Level 100
solubility DMSO: >10 mg/mL, H₂O: 2 mg/mL	solubility DMSO: 11 mg/mL, ethanol: 2.7 mg/mL, H₂O: 3 mg/mL	solubility H₂O: >10 mg/mL, DMSO: 12 mg/mL, ethanol: 3 mg/mL	solubility H₂O: >10 mg/mL, DMSO: 100 mg/mL
color white to off-white	color off-white	color white	color white to off-white
Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)	Gene Information human ... DRD4(1815)	Gene Information human ... HRH3(11255)	Gene Information human ... ADRB1(153)
originator Novartis	originator -	originator -	originator -