SRP6509

Chymotrypsin from human pancreas

≥95% (SDS-PAGE)

• Synonyme(s) : CLCR, CTRC, CTRC_HUMAN, Caldecrin, Chymotrypsin C, Chymotrypsin-C, ELA 4, Elastase 4, Elastase IV, Serum calcium decreasing factor
• Numéro CE : 232-671-2
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.78

Propriétés

• Source biologique: human
• Pureté: ≥95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: 25 kDa
• Conditionnement: pkg of 100 μg
• Numéro d'accès UniProt: Q99895
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... CTRC(11330)

Description

Description générale

Chymotrypsin from human pancreas is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. It is secreted by the pancreas as inactive chymotrypsinogen C. Molecular weight of this enzyme is found to be 25kDa. The pI is 8.75.

Actions biochimiques/physiologiques

Chymotrypsin from human pancreas selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan and leucine. Loss-of-function mutations in this gene have been associated with increased risk of chronic pancreatitis. It has high activity toward leucyl peptide bonds. The enzyme acts as a co-activator of procarboxypeptidases A1 and A2.

Forme physique

Lyophilized as a salt-free solid.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H319,H334,H335,H400
• Conseils de prudence: P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1