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N4126

Sigma-Aldrich

Acide nicotinique

≥98%

Synonyme(s) :

Acide 3-picolinique, Acide pyridine-3-carboxylique, Facteur de prévention de la pellagre

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About This Item

Formule empirique (notation de Hill) :
C6H5NO2
Numéro CAS:
59-67-6
Poids moléculaire :
123.11
Beilstein:
109591
Numéro CE :
200-441-0
Numéro MDL:
MFCD00006391
Code UNSPSC :
12352106
ID de substance PubChem :
24897668
Nomenclature NACRES :
NA.25
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

synthetic (organic)

Niveau de qualité

200

Essai

≥98%

Forme

powder

Couleur

white to off-white

Pf

236-239 °C (lit.)

Chaîne SMILES 

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

Clé InChI

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Informations sur le gène

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Catégories apparentées

Description générale

Nicotinic acid is also known as vitamin B3 or Niacin. It is a water soluble vitamin. Niacin can be either synthesized within the body or can be obtained from dietary sources.[1]

Application

Nicotinic acid has been used:
  • as a component of the MS vitamins stock solution[2]
  • for the detection of siderophores in Escherichia coli bacterial culture[3]
  • as a component of the holidic medium for adult Drosophila [4].

Actions biochimiques/physiologiques

Niacin is involved in the production of nicotinamide adenine dinucleotide (NAD+), which is used in the adenine triphosphate (ATP) production in mitochondrial oxidative phosphorylation.[1] It also decreases hepatic production of very-low density lipoproteins (VLDL), and apolipoprotein B (apo-B).[5] Niacin deficiency leads to pellagra.[6]

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

379.4 °F - closed cup

Point d'éclair (°C)

193 °C - closed cup

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000427849
0000427849
0000422878
0000422897
0000422897

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Vitamin B3 and sirtuin function
Denu J M
Trends in Biochemical Sciences, 30(9), 479-483 (2005)
A procedure allowing up to eight generations of wheat and nine generations of barley per annum
Zheng Z, et al.
Euphytica, 191(2), 311-316 (2013)
A holidic medium for Drosophila melanogaster
Piper M D W, et al.
Nature Methods, 11(1), 100-100 (2014)
An investigation into the pathogenic properties of Escherichia coli strains BLR, BL21, DH5 alpha and EQ1
Chart H, et al.
Journal of Applied Microbiology, 89(6), 1048-1058 (2000)
Mechanism of action of niacin
Kamanna V S and Kashyap M L
The American Journal of Cardiology, 101(8), S20-S26 (2008)
Afficher tous les articles scientifiques apparentés

Articles

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Bonjour, s'il vous plaît dites-moi, ce médicament est-il en ampoules ?

    1 answer

    1. This product is not suitable for human use, it is intended for research use only. This material is in powder form and is packaged in High Density Polyethylene (HDPE) plastic bottles.

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